Endoglin/CD105 Antibody (SN6): sc-57099

Endoglin Antibody (SN6) is a mouse monoclonal IgG1 antibody that detects Endoglin in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Endoglin, also known as CD105, plays a crucial role in angiogenesis and vascular development, making Endoglin essential for maintaining normal blood vessel structure and function. Endoglin is primarily located on the surface of vascular endothelial cells, where Endoglin acts as a co-receptor for transforming growth factor-beta (TGF-β) superfamily ligands, facilitating signaling pathways that regulate cell proliferation, migration, and differentiation. Endoglin′s location in the cell is critical, as Endoglin′s interaction with TGF-β ligands is vital for proper endothelial function and the formation of new blood vessels. Dysregulation of Endoglin expression or function can lead to severe vascular abnormalities, as seen in hereditary hemorrhagic telangiectasia (HHT), underscoring Endoglin′s significance in both health and disease. Anti-Endoglin antibody (SN6) is an invaluable tool for researchers studying vascular biology and related disorders, providing insights into the mechanisms underlying angiogenesis and potential therapeutic targets.

The preferred Endoglin/CD105 antibody is Endoglin/CD105 Antibody (P3D1): sc-18838.