Endoglin/CD105 Antibody (P3D1): sc-18838

Endoglin Antibody (P3D1) is a mouse monoclonal IgG2a kappa light chain antibody that detects the Endoglin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Endoglin monoclonal antibody (P3D1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Endoglin, also known as CD105, plays a crucial role in angiogenesis and is essential for the proper formation of blood vessels. Endoglin is primarily located on the surface of vascular endothelial cells, where Endoglin interacts with transforming growth factor-beta (TGF-β) superfamily ligands, facilitating their signaling pathways that regulate cell proliferation, migration, and differentiation. The importance of Endoglin in vascular biology is underscored by Endoglin′s involvement in hereditary hemorrhagic telangiectasia (HHT), a genetic disorder characterized by abnormal blood vessel formation leading to excessive bleeding and other vascular complications. Mutations in the Endoglin gene can disrupt Endoglin′s function, contributing to the pathophysiology of HHT1, highlighting the significance of this protein in maintaining vascular integrity and function.

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Endoglin/CD105 Antibody (P3D1) References:

1. Novel missense and frameshift mutations in the activin receptor-like kinase-1 gene in hereditary hemorrhagic telangiectasia. Mutations in brief no. 164. Online.  |  Klaus, DJ., et al. 1998. Hum Mutat. 12: 137. PMID: 10694922
2. Two common endoglin mutations in families with hereditary hemorrhagic telangiectasia in the Netherlands Antilles: evidence for a founder effect.  |  Gallione, CJ., et al. 2000. Hum Genet. 107: 40-4. PMID: 10982033
3. Genetic and molecular pathogenesis of hereditary hemorrhagic telangiectasia.  |  Azuma, H. 2000. J Med Invest. 47: 81-90. PMID: 11019486
4. Endoglin-deficient mice, a unique model to study hereditary hemorrhagic telangiectasia.  |  Bourdeau, A., et al. 2000. Trends Cardiovasc Med. 10: 279-85. PMID: 11343967
5. Potential role of modifier genes influencing transforming growth factor-beta1 levels in the development of vascular defects in endoglin heterozygous mice with hereditary hemorrhagic telangiectasia.  |  Bourdeau, A., et al. 2001. Am J Pathol. 158: 2011-20. PMID: 11395379
6. ENG mutations in MADH4/BMPR1A mutation negative patients with juvenile polyposis.  |  Howe, JR., et al. 2007. Clin Genet. 71: 91-2. PMID: 17204053
7. Endoglin: a critical mediator of cardiovascular health.  |  Kapur, NK., et al. 2013. Vasc Health Risk Manag. 9: 195-206. PMID: 23662065
8. Soluble endoglin reduces thrombus formation and platelet aggregation via interaction with αIIbβ3 integrin.  |  Rossi, E., et al. 2023. J Thromb Haemost. 21: 1943-1956. PMID: 36990159
9. Endoglin and soluble endoglin in liver sinusoidal endothelial dysfunction in vivo.  |  Eissazadeh, S., et al. 2024. Biochim Biophys Acta Mol Basis Dis. 1870: 166990. PMID: 38110128
10. Cloning and characterization of the murine activin receptor like kinase-1 (ALK-1) homolog.  |  Wu, X., et al. 1995. Biochem Biophys Res Commun. 216: 78-83. PMID: 7488127
11. Expression and structural features of endoglin (CD105), a transforming growth factor beta1 and beta3 binding protein, in human melanoma.  |  Altomonte, M., et al. 1996. Br J Cancer. 74: 1586-91. PMID: 8932339
12. Mutation and expression analysis of the endoglin gene in hereditary hemorrhagic telangiectasia reveals null alleles.  |  Gallione, CJ., et al. 1998. Hum Mutat. 11: 286-94. PMID: 9554745

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Endoglin/CD105 Antibody (P3D1) has 37 citations in a variety of scientific publications.

Primary antibodies like Anti-Endoglin/CD105 Antibody (P3D1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Endoglin/CD105 Antibody (P3D1) Specifications

Alternate Product Name: CD105

Product Clone Name: P3D1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids:

Epitope Target: Endoglin

Epitope Species: human

Product Reactivity/Detection: TGF-Receptor III complex (known also as Endoglin or CD105) of Endoglin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 37 citations in various scientific publications

Available Conjugates/Forms for Endoglin/CD105 Antibody (P3D1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin