Endoglin/CD105 Antibody (A-8): sc-376381

Endoglin Antibody (A-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects Endoglin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Endoglin antibody (A-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Endoglin, also known as CD105, plays a crucial role in angiogenesis and is a co-receptor for transforming growth factor-beta (TGF-β) superfamily members, which are essential for regulating vascular development and homeostasis. Endoglin is primarily located on the surface of vascular endothelial cells, where Endoglin facilitates the binding of TGF-β ligands to their respective receptors, thereby influencing cellular responses vital for maintaining blood vessel integrity and function. Mutations in Endoglin are associated with hereditary hemorrhagic telangiectasia (HHT), a genetic disorder characterized by abnormal blood vessel formation, leading to symptoms such as excessive bleeding and vascular malformations. Understanding Endoglin′s function and location is important for elucidating Endoglin′s role in vascular biology and the pathogenesis of related diseases, making Endoglin monoclonal antibody (A-8) a valuable tool for researchers studying endothelial function and vascular disorders.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Endoglin/CD105 Antibody (A-8) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-Endoglin/CD105 Antibody (A-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Endoglin/CD105 Antibody (A-8) Specifications

Alternate Product Name: CD105

Product Clone Name: A-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 27-326

Epitope Target: Endoglin

Epitope Species: human

Product Reactivity/Detection: Endoglin dimer under non-reducing conditions, and Endoglin monomer under reducing conditions

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for Endoglin/CD105 Antibody (A-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Endoglin/CD105 antibody is Endoglin/CD105 Antibody (P3D1): sc-18838.