Enamelin Antibody (2C12): sc-293334
- Enamelin Antibody (2C12) is a mouse monoclonal IgG2a κ Enamelin antibody provided at 100 µg/ml
- raised against amino acids 1043-1141 of Enamelin of human origin
- recommended for detection of Enamelin of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Enamelin Antibody (2C12). This work is in progress.
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Enamelin Antibody (2C12) is a mouse monoclonal IgG2a kappa light chain antibody that detects the Enamelin protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Enamelin antibody (2C12) is available as the non-conjugated form. Enamelin (ENAM) plays a crucial role in the formation and mineralization of dental enamel, a highly mineralized tissue primarily composed of hydroxyapatite crystals. ENAM is secreted by ameloblasts during the secretory stage of enamel development and is essential for the proper extension and organization of enamel. ENAM localizes to the extracellular matrix, where ENAM interacts with other key proteins such as Amelogenin and Ameloblastin, contributing to the structural integrity and functionality of the enamel matrix. Deficiencies or mutations in the ENAM gene can lead to hypoplastic amelogenesis imperfecta 2 (AIH2), an autosomal dominant condition that results in significant enamel defects, highlighting the importance of ENAM in dental health. Anti-Enamelin antibody (2C12) effectively detects ENAM, making this reagent a valuable tool for researchers studying enamel formation and related dental disorders.
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Enamelin Antibody (2C12) References:
- Cloning human enamelin cDNA, chromosomal localization, and analysis of expression during tooth development. | Hu, CC., et al. 2000. J Dent Res. 79: 912-9. PMID: 10831092
- Enamelin and autosomal-dominant amelogenesis imperfecta. | Hu, JC. and Yamakoshi, Y. 2003. Crit Rev Oral Biol Med. 14: 387-98. PMID: 14656895
- Enamelin (Enam) is essential for amelogenesis: ENU-induced mouse mutants as models for different clinical subtypes of human amelogenesis imperfecta (AI). | Masuya, H., et al. 2005. Hum Mol Genet. 14: 575-83. PMID: 15649948
- ENAM mutations in autosomal-dominant amelogenesis imperfecta. | Kim, JW., et al. 2005. J Dent Res. 84: 278-82. PMID: 15723871
- Characterization of epithelial cells derived from periodontal ligament by gene expression patterns of bone-related and enamel proteins. | Mizuno, N., et al. 2005. Cell Biol Int. 29: 111-7. PMID: 15774307
- Ameloblastin and amelogenin expression in posnatal developing mouse molars. | Torres-Quintana, MA., et al. 2005. J Oral Sci. 47: 27-34. PMID: 15881226
- Enamel matrix protein interactions. | Wang, H., et al. 2005. J Bone Miner Res. 20: 1032-40. PMID: 15883644
- Tooth developmental biology: disruptions to enamel-matrix assembly and its impact on biomineralization. | Paine, ML. and Snead, ML. 2005. Orthod Craniofac Res. 8: 239-51. PMID: 16238604
- Enamelin is critical for ameloblast integrity and enamel ultrastructure formation. | Hu, JC., et al. 2014. PLoS One. 9: e89303. PMID: 24603688
- The phosphorylation of serine55 in enamelin is essential for murine amelogenesis. | Dong, C., et al. 2022. Matrix Biol. 111: 245-263. PMID: 35820561
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Enamelin Antibody (2C12) | sc-293334 | 100 µg/ml | $316.00 |