EMP-3 Antibody (SW-5): sc-81797

EMP-3 Antibody (SW-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects EMP-3 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-EMP-3 antibody (SW-5) is available as the non-conjugated format. EMP-3, also known as epithelial membrane protein 3 or YMP, is a 163 amino acid multi-pass membrane protein characterized by two N-linked glycosylation sites and four transmembrane domains. EMP-3 is predominantly expressed in peripheral blood leukocytes and plays a crucial role in cell-cell interactions and cell proliferation, which are vital for maintaining tissue homeostasis and immune responses. Notably, EMP-3 has been implicated as a potential tumor suppressor, as EMP-3 can silence CpG promoter activity, thereby inhibiting the growth of neuroblastomas and gliomas. However, overexpression of EMP-3 has been associated with the development of oligodendroglial tumors, which arise from the myelin-producing cells of the central nervous system. The dual role of EMP-3 in both repressing and promoting tumor formation highlights EMP-3′s importance in cancer biology, suggesting that while normal levels may help to keep tumor activity in check, elevated expression could contribute to carcinogenesis.

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EMP-3 Antibody (SW-5) References:

1. Regional localization of the human epithelial membrane protein genes 1, 2, and 3 (EMP1, EMP2, EMP3) to 12p12.3, 16p13.2, and 19q13.3.  |  Liehr, T., et al. 1999. Genomics. 58: 106-8. PMID: 10331954
2. A single nucleotide polymorphism in the Emp3 gene defines the H4 minor histocompatibility antigen.  |  Luedtke, B., et al. 2003. Immunogenetics. 55: 284-95. PMID: 12845499
3. EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastoma.  |  Alaminos, M., et al. 2005. Cancer Res. 65: 2565-71. PMID: 15805250
4. Altered expression of CLC, DSG3, EMP3, S100A2, and SLPI in corneal epithelium from keratoconus patients.  |  Nielsen, K., et al. 2005. Cornea. 24: 661-8. PMID: 16015083
5. Trafficking determinants for PfEMP3 export and assembly under the Plasmodium falciparum-infected red blood cell membrane.  |  Knuepfer, E., et al. 2005. Mol Microbiol. 58: 1039-53. PMID: 16262789
6. EMP3 overexpression is associated with oligodendroglial tumors retaining chromosome arms 1p and 19q.  |  Li, KK., et al. 2007. Int J Cancer. 120: 947-50. PMID: 17187361
7. DNA hypermethylation and aberrant expression of the EMP3 gene at 19q13.3 in Human Gliomas.  |  Kunitz, A., et al. 2007. Brain Pathol. 17: 363-70. PMID: 17610521
8. Epithelial membrane protein-2 and epithelial membrane protein-3: two novel members of the peripheral myelin protein 22 gene family.  |  Taylor, V. and Suter, U. 1996. Gene. 175: 115-20. PMID: 8917086
9. Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins.  |  Ben-Porath, I. and Benvenisty, N. 1996. Gene. 183: 69-75. PMID: 8996089

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-EMP-3 Antibody (SW-5) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-EMP-3 Antibody (SW-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

EMP-3 Antibody (SW-5) Specifications

Alternate Product Name: EMP-3

Product Clone Name: SW-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-164

Epitope Target: EMP-3

Epitope Species: human

Product Reactivity/Detection: EMP-3

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for EMP-3 Antibody (SW-5): N/A