EMMPRIN/CD147 Antibody (OX114): sc-53064

EMMPRIN Antibody (OX114) is a rat monoclonal IgG1 antibody that detects EMMPRIN in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). EMMPRIN, also known as basigin or CD147, plays a crucial role in the regulation of matrix remodeling at the epidermal-dermal interface, where EMMPRIN stimulates fibroblasts to produce key enzymes such as interstitial collagenase, gelatinase A, and stromelysin-1, along with various metalloproteinases (MMPs). These enzymes are particularly significant during tissue degradation and wound healing, as MMPs facilitate the breakdown of extracellular matrix components, which is essential for normal physiological processes. Importantly, dysregulation of EMMPRIN and associated metalloproteinases has been implicated in cancer invasion and metastasis, making EMMPRIN a critical target for understanding tumor progression and developing therapeutic strategies. Anti-EMMPRIN antibody (OX114) provides a valuable tool for researchers investigating the complex roles of EMMPRIN in both normal and pathological conditions.

The preferred EMMPRIN/CD147 antibody is EMMPRIN/CD147 Antibody (8D6): sc-21746.