EMMPRIN/CD147 Antibody (8D6): sc-21746

EMMPRIN Antibody (8D6) is a mouse monoclonal IgG1 kappa light chain antibody that detects EMMPRIN protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). EMMPRIN (8D6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. EMMPRIN protein, also known as basigin or CD147, plays a crucial role in the regulation of matrix remodeling at the epidermal-dermal interface, which is vital for maintaining skin integrity and facilitating wound healing. EMMPRIN stimulates the production of matrix metalloproteinases (MMPs) such as interstitial collagenase, gelatinase A, and stromelysin-1 by fibroblasts, which are essential for tissue remodeling during both normal physiological processes and pathological conditions, including cancer invasion and metastasis. EMMPRIN′s ability to modulate MMP activity underscores its importance in both tissue homeostasis and the progression of various diseases, making anti-EMMPRIN antibody (8D6) a valuable tool for researchers studying these critical biological processes.

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EMMPRIN/CD147 Antibody (8D6) References:

1. Matrix metalloproteinases and their inhibitors in tumour growth and invasion.  |  Kähäri, VM. and Saarialho-Kere, U. 1999. Ann Med. 31: 34-45. PMID: 10219712
2. T cell activation-associated epitopes of CD147 in regulation of the T cell response, and their definition by antibody affinity and antigen density.  |  Koch, C., et al. 1999. Int Immunol. 11: 777-86. PMID: 10330283
3. VEGF and EMMPRIN expression correlates with survival of patients with osteosarcoma.  |  Zhou, Q., et al. 2011. Surg Oncol. 20: 13-9. PMID: 19836228
4. Basigin, a new, broadly distributed member of the immunoglobulin superfamily, has strong homology with both the immunoglobulin V domain and the beta-chain of major histocompatibility complex class II antigen.  |  Miyauchi, T., et al. 1990. J Biochem. 107: 316-23. PMID: 2361961
5. EMMPRIN, an upstream regulator of MMPs, in CNS biology.  |  Kaushik, DK., et al. 2015. Matrix Biol. 44-46: 138-46. PMID: 25644103
6. Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts.  |  Paterson, DJ., et al. 1987. Mol Immunol. 24: 1281-90. PMID: 2828930
7. EMMPRIN is an emerging protein capable of regulating cancer hallmarks.  |  de la Cruz Concepción, B., et al. 2022. Eur Rev Med Pharmacol Sci. 26: 6700-6724. PMID: 36196720
8. The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily.  |  Biswas, C., et al. 1995. Cancer Res. 55: 434-9. PMID: 7812975
9. Human keratinocytes express EMMPRIN, an extracellular matrix metalloproteinase inducer.  |  DeCastro, R., et al. 1996. J Invest Dermatol. 106: 1260-5. PMID: 8752667
10. Stimulation of matrix metalloproteinase production by recombinant extracellular matrix metalloproteinase inducer from transfected Chinese hamster ovary cells.  |  Guo, H., et al. 1997. J Biol Chem. 272: 24-7. PMID: 8995219
11. Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases.  |  Guo, H., et al. 1998. Gene. 220: 99-108. PMID: 9767135
12. Tumor-derived EMMPRIN (extracellular matrix metalloproteinase inducer) stimulates collagenase transcription through MAPK p38.  |  Lim, M., et al. 1998. FEBS Lett. 441: 88-92. PMID: 9877171

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-EMMPRIN/CD147 Antibody (8D6) has 60 citations in a variety of scientific publications.

Primary antibodies like Anti-EMMPRIN/CD147 Antibody (8D6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

EMMPRIN/CD147 Antibody (8D6) Specifications

Alternate Product Name: EMMPRIN

Product Clone Name: 8D6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: EMMPRIN

Epitope Species: human

Product Reactivity/Detection: EMMPRIN

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 60 citations in various scientific publications

Available Conjugates/Forms for EMMPRIN/CD147 Antibody (8D6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin