EMILIN-1 Antibody (C-6): sc-365737
- EMILIN-1 Antibody (C-6) is a mouse monoclonal IgG1 κ EMILIN-1 antibody provided at 200 µg/ml
- raised against amino acids 187-266 mapping within an internal region of EMILIN-1 of human origin
- EMILIN-1 Antibody (C-6) is recommended for detection of EMILIN-1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-EMILIN-1 Antibody (C-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for EMILIN-1 Antibody (C-6) for WB applications. This reagent is now offered in a bundle with EMILIN-1 Antibody (C-6) (see ordering information below).
QUICK LINKS
EMILIN-1 Antibody (C-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects EMILIN-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). EMILIN-1 (C-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. EMILIN-1, also known as elastin microfibril interface located protein, plays a crucial role in the extracellular matrix, particularly at the interface of elastin and microfibrils, which is vital for maintaining the structural integrity and elasticity of tissues. EMILIN-1 is predominantly found in elastin-rich tissues such as blood vessels, skin, heart, and lung, where anti-EMILIN-1 antibody (C-6) can help study formation of the extracellular matrix and processes like placenta formation and organogenesis. EMILIN-1 is involved in the regulation of cell adhesion and migration, making EMILIN-1 monoclonal antibody (C-6) significant in developmental biology and tissue repair research. EMILIN-1′s interaction with other extracellular matrix components underscores its importance in maintaining tissue homeostasis and responding to injury, highlighting EMILIN-1 (C-6) antibody′s relevance in research focused on cardiovascular health, wound healing, and developmental processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
EMILIN-1 Antibody (C-6) References:
- EMILIN, a component of the elastic fiber and a new member of the C1q/tumor necrosis factor superfamily of proteins. | Doliana, R., et al. 1999. J Biol Chem. 274: 16773-81. PMID: 10358019
- Self-assembly and supramolecular organization of EMILIN. | Mongiat, M., et al. 2000. J Biol Chem. 275: 25471-80. PMID: 10821830
- beta 1 Integrin-dependent cell adhesion to EMILIN-1 is mediated by the gC1q domain. | Spessotto, P., et al. 2003. J Biol Chem. 278: 6160-7. PMID: 12456677
- Expression of the EMILIN-1 gene during mouse development. | Braghetta, P., et al. 2002. Matrix Biol. 21: 603-9. PMID: 12475644
- EMILIN-1 deficiency induces elastogenesis and vascular cell defects. | Zanetti, M., et al. 2004. Mol Cell Biol. 24: 638-50. PMID: 14701737
- Sequence-specific backbone NMR assignments for the C-terminal globular domain of EMILIN-1. | Verdone, G., et al. 2004. J Biomol NMR. 29: 91-2. PMID: 15017143
- EMILIN-1 regulates the amount of oxytalan fiber formation in periodontal ligaments in vitro. | Nakatomi, Y., et al. 2011. Connect Tissue Res. 52: 30-5. PMID: 20701466
- Targeting of EMILIN-1 and EMILIN-2 to Fibrillin Microfibrils Facilitates their Incorporation into the Extracellular Matrix. | Schiavinato, A., et al. 2016. J Invest Dermatol. 136: 1150-1160. PMID: 26945878
- Elastin MIcrofibriL INterfacer1 (EMILIN-1) is an alternative prosurvival VLA-4 ligand in chronic lymphocytic leukemia. | Tissino, E., et al. 2022. Hematol Oncol. 40: 181-190. PMID: 34783040
- EMILIN-1 deficiency promotes chronic inflammatory disease through TGFβ signaling alteration and impairment of the gC1q/α4β1 integrin interaction. | Pivetta, E., et al. 2022. Matrix Biol. 111: 133-152. PMID: 35764213
- The role of EMILIN-1 in the osteo/odontogenic differentiation of dental pulp stem cells. | Deng, P., et al. 2023. BMC Oral Health. 23: 203. PMID: 37024847
- The extracellular matrix protein EMILIN-1 impacts on the microenvironment by hampering gastric cancer development and progression. | Capuano, A., et al. 2024. Gastric Cancer. 27: 1016-1030. PMID: 38941035
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EMILIN-1 Antibody (C-6) | sc-365737 | 200 µg/ml | $322.00 | |||
EMILIN-1 Antibody (C-6): m-IgG Fc BP-HRP Bundle | sc-525899 | 200 µg Ab; 10 µg BP | $361.00 | |||
EMILIN-1 Antibody (C-6) AC | sc-365737 AC | 500 µg/ml, 25% agarose | $424.00 | |||
EMILIN-1 Antibody (C-6) HRP | sc-365737 HRP | 200 µg/ml | $322.00 | |||
EMILIN-1 Antibody (C-6) FITC | sc-365737 FITC | 200 µg/ml | $336.00 | |||
EMILIN-1 Antibody (C-6) PE | sc-365737 PE | 200 µg/ml | $349.00 | |||
EMILIN-1 Antibody (C-6) Alexa Fluor® 488 | sc-365737 AF488 | 200 µg/ml | $364.00 | |||
EMILIN-1 Antibody (C-6) Alexa Fluor® 546 | sc-365737 AF546 | 200 µg/ml | $364.00 | |||
EMILIN-1 Antibody (C-6) Alexa Fluor® 594 | sc-365737 AF594 | 200 µg/ml | $364.00 | |||
EMILIN-1 Antibody (C-6) Alexa Fluor® 647 | sc-365737 AF647 | 200 µg/ml | $364.00 | |||
EMILIN-1 Antibody (C-6) Alexa Fluor® 680 | sc-365737 AF680 | 200 µg/ml | $364.00 | |||
EMILIN-1 Antibody (C-6) Alexa Fluor® 790 | sc-365737 AF790 | 200 µg/ml | $364.00 |