Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Emi2 Antibody (4B6) is a high quality monoclonal Emi2 antibody (also designated Emi2 antibody) suitable for the detection of the Emi2 protein of human origin. Emi2 Antibody (4B6) is available as the non-conjugated anti-Emi2 antibody. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune responses, signaling cascades and developmental events) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, IκB-α and β-catenin, for proteasomal degradation. Emi2 (endogenous meiotic inhibitor 2), also known as FBXO43 (F-box only protein 43) or ERP1, is a 708 amino acid protein that contains one F-box domain and one IBR-type zinc finger. Playing an important role in protein modification, Emi2 is required for the establishment and maintenance of oocyte arrest at the second meiotic metaphase, an event that is crucial for fertilization. Specifically, Emi2 is thought to induce meiotic arrest by inhibiting the activity of the APC (anaphase-promoting complex), thereby preventing the progression of meiosis. Emi2 is subject to phosphorylation and ubiquitination, both of which promote its degradation by the proteasome.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
For Western Blot, is it recommended to use denatured or non-denatured conditions with Emi2 (4B6): sc-517089 antibody?
Asked by: Dr Ninau Qelp
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
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