EMAP II Antibody (A-4): sc-393228

EMAP II Antibody (A-4) is a mouse monoclonal IgM antibody that detects EMAP II of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-EMAP II antibody (A-4) is available as the non-conjugated form. Endothelial monocyte-activating polypeptide II (EMAP II), also known as small inducible cytokine subfamily E, member 1 (SCYE1), plays a crucial role as a chemoattractant cytokine for monocytes and granulocytes, particularly in inflammation and immune response. EMAP II is primarily located in the extracellular space, where various cell types, including tumor cells, secrete this protein. EMAP II′s presence in the tumor microenvironment significantly influences immune cell behavior and the vascular system. EMAP II is induced by apoptotic signals, and release of EMAP II can sensitize tumor-associated vasculature to tumor necrosis factor, enhancing anti-tumor therapy efficacy. ProEMAP II, the precursor form, undergoes proteolytic cleavage to yield the mature, biologically active cytokine, which mediates inflammatory responses. ProEMAP II may also bind RNA as part of the tRNA synthetase complex in normal cells, highlighting multiple functions in both physiological and pathological contexts.

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EMAP II Antibody (A-4) References:

1. Expression of EMAP II in the developing and adult mouse.  |  Knies, UE., et al. 2000. Apoptosis. 5: 141-51. PMID: 11232242
2. Expression of EMAP-II by activated monocytes/microglial cells in different regions of the rat hippocampus after trimethyltin-induced brain damage.  |  Brabeck, C., et al. 2002. Exp Neurol. 177: 341-6. PMID: 12429238
3. Regulation of EMAP II by hypoxia.  |  Matschurat, S., et al. 2003. Am J Pathol. 162: 93-103. PMID: 12507893
4. Lesional expression of a proinflammatory and antiangiogenic cytokine EMAP II confined to endothelium and microglia/macrophages during secondary damage following experimental traumatic brain injury.  |  Mueller, CA., et al. 2003. J Neuroimmunol. 135: 1-9. PMID: 12576219
5. Spinal cord injury induces lesional expression of the proinflammatory and antiangiogenic cytokine EMAP II.  |  Mueller, CA., et al. 2003. J Neurotrauma. 20: 1007-15. PMID: 14588117
6. Endothelial monocyte-activating polypeptide-II (EMAP-II): a novel inducer of lymphocyte apoptosis.  |  Murray, JC., et al. 2004. J Leukoc Biol. 75: 772-6. PMID: 14982944

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-EMAP II Antibody (A-4) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-EMAP II Antibody (A-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

EMAP II Antibody (A-4) Specifications

Alternate Product Name: EMAP II

Product Clone Name: A-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 268-289

Epitope Target: EMAP II

Epitope Species: human

Product Reactivity/Detection: precursor and mature EMAP II

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for EMAP II Antibody (A-4): P: Blocking Peptide