ELYS Antibody (2318C1a): sc-81265

ELYS Antibody (2318C2a) is a mouse monoclonal IgG1 antibody that detects the ELYS protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-ELYS antibody (2318C2a) is available as a non-conjugated format. ELYS, also known as AT-hook-containing transcription factor 1, is a crucial protein located within the nuclear matrix, characterized by its single AT hook DNA-binding domain. ELYS plays a vital role in nuclear pore assembly and is essential for proper cell division, as nuclear pores serve as gated channels that regulate the transport of macromolecules between the nucleus and cytoplasm, including proteins, RNAs, and entire viral genomes. The presence of the AT hook domain suggests ELYS may also function as a transcription factor, potentially influencing gene expression in hematopoietic tissues. ELYS is critical for early embryonic development, particularly in the survival of inner cells of the blastocyst, highlighting its importance in developmental biology and cellular integrity.

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ELYS Antibody (2318C1a) References:

1. Identification of a novel transcription factor, ELYS, expressed predominantly in mouse foetal haematopoietic tissues.  |  Kimura, N., et al. 2002. Genes Cells. 7: 435-46. PMID: 11952839
2. Genomic organization and characterization of the mouse ELYS gene.  |  Okita, K., et al. 2003. Biochem Biophys Res Commun. 305: 327-32. PMID: 12745078
3. Targeted disruption of the mouse ELYS gene results in embryonic death at peri-implantation development.  |  Okita, K., et al. 2004. Genes Cells. 9: 1083-91. PMID: 15507119
4. ELYS is a dual nucleoporin/kinetochore protein required for nuclear pore assembly and proper cell division.  |  Rasala, BA., et al. 2006. Proc Natl Acad Sci U S A. 103: 17801-6. PMID: 17098863
5. MEL-28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly.  |  Franz, C., et al. 2007. EMBO Rep. 8: 165-72. PMID: 17235358
6. ELYS/MEL-28 chromatin association coordinates nuclear pore complex assembly and replication licensing.  |  Gillespie, PJ., et al. 2007. Curr Biol. 17: 1657-62. PMID: 17825564
7. Centrin 2 localizes to the vertebrate nuclear pore and plays a role in mRNA and protein export.  |  Resendes, KK., et al. 2008. Mol Cell Biol. 28: 1755-69. PMID: 18172010

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ELYS Antibody (2318C1a) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-ELYS Antibody (2318C1a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ELYS Antibody (2318C1a) Specifications

Alternate Product Name: ELYS

Product Clone Name: 2318C1a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: ELYS

Epitope Species: human

Product Reactivity/Detection: ELYS

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for ELYS Antibody (2318C1a): N/A