eIF2Bγ Antibody (D-8): sc-166768
- eIF2Bγ Antibody (D-8) is a mouse monoclonal IgM κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 153-452 mapping at the C-terminus of eIF2Bγ of human origin
- recommended for detection of eIF2Bγ of human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for eIF2Bγ Antibody (D-8) for WB and IHC(P) applications. This reagent is now offered in a bundle with eIF2Bγ Antibody (D-8) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
eIF2Bγ Antibody (D-8) is a mouse monoclonal IgM antibody that detects eIF2Bγ in human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). eIF2Bγ is a crucial component of the eukaryotic initiation factor 2B (eIF2B) complex, which plays a vital role in protein synthesis regulation by facilitating GDP to GTP exchange on the eIF2 complex. This exchange enables formation of the eIF2-GTP-40S ribosomal subunit complex, a key step in translation initiation. Proper functioning of eIF2Bγ and interactions with other eIF2B subunits maintain cellular homeostasis and stress responses, as dysregulation can impair protein synthesis and contribute to various diseases, including neurodegenerative disorders. eIF2B complex activity is modulated by phosphorylation events, particularly of eIF2, which can inhibit guanine nucleotide exchange factor activity of eIF2B, highlighting eIF2Bγ′s importance in cellular signaling pathways. anti-eIF2Bγ antibody (D-8) serves as an invaluable tool for researchers studying translation initiation and its implications in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
eIF2Bγ Antibody (D-8) | sc-166768 | 200 µg/ml | $322.00 | |||
eIF2Bγ Antibody (D-8): m-IgGκ BP-HRP Bundle | sc-550740 | 200 µg Ab; 40 µg BP | $361.00 |