eIF2Bγ Antibody (C-11): sc-137248
- eIF2Bγ Antibody (C-11) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 153-452 mapping near the C-terminus of eIF2Bγ of human origin
- recommended for detection of eIF2Bγ of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for eIF2Bγ Antibody (C-11) for WB applications. These reagents are now offered in bundles with eIF2Bγ Antibody (C-11) (see ordering information below).
eIF2Bγ Antibody (C-11) is a mouse monoclonal IgG1 antibody that detects eIF2Bγ in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). eIF2Bγ is a crucial component of the eukaryotic initiation factor 2B complex, which plays a vital role in protein synthesis regulation by facilitating GDP to GTP exchange on the eIF2 complex. This exchange is essential for forming the eukaryotic initiation complex, necessary for translation initiation. Proper functioning of eIF2Bγ and associated subunits is critical, as dysregulation can lead to impaired protein synthesis and has been linked to various diseases, including neurodegenerative disorders and cancer. The eIF2B complex, consisting of eIF2Bα, eIF2Bβ, eIF2Bγ, eIF2Bδ, and eIF2Bε, exhibits guanine nucleotide exchange factor activity, with eIF2Bε being the primary contributor. Notably, eIF2 phosphorylation can inhibit eIF2B′s guanine nucleotide exchange factor activity, a process dependent on the eIF2Bα subunit. anti-eIF2Bγ antibody (C-11) serves as an invaluable tool for researchers studying protein synthesis mechanisms and regulation in various biological contexts.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
eIF2Bγ Antibody (C-11) | sc-137248 | 200 µg/ml | $322.00 | |||
eIF2Bγ Antibody (C-11): m-IgG Fc BP-HRP Bundle | sc-539969 | 200 µg Ab; 10 µg BP | $361.00 | |||
eIF2Bγ Antibody (C-11): m-IgG1 BP-HRP Bundle | sc-541822 | 200 µg Ab; 20 µg BP | $361.00 |