eIF2β Antibody (C-1): sc-133133
- eIF2β Antibody (C-1) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- raised against amino acids 131-333 mapping at the C-terminus of eIF2β of human origin
- recommended for detection of eIF2β of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG3 BP-HRP is the preferred secondary detection reagent for eIF2β Antibody (C-1) for WB and IHC(P) applications. This reagent is now offered in a bundle with eIF2β Antibody (C-1) (see ordering information below).
eIF2β Antibody (C-1) is a mouse monoclonal IgG3 antibody that detects eIF2β in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). eIF2β, a critical component of the eukaryotic initiation factor 2B complex, plays a vital role in protein synthesis regulation by facilitating GDP to GTP exchange on the eIF2 complex, essential for translation initiation. eIF2β is located in the cytoplasm, where eIF2β interacts with other initiation factors and ribosomal subunits to form the eukaryotic initiation complex, ensuring proper assembly of the translation machinery. eIF2β′s cellular location directly influences protein synthesis efficiency, crucial for cellular function and stress response. The eIF2B complex consists of five subunits—eIF2Bα, eIF2Bβ, eIF2Bγ, eIF2Bδ, and eIF2Bε—each contributing to guanine nucleotide exchange factor activity, with eIF2Bε showing highest activity. eIF2 phosphorylation inhibits eIF2B′s guanine nucleotide exchange factor activity, demonstrating regulatory mechanisms controlling protein synthesis during cellular stress, making eIF2β significant for research in translation regulation and disease implications.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
eIF2β Antibody (C-1) | sc-133133 | 200 µg/ml | $322.00 | |||
eIF2β Antibody (C-1): m-IgG3 BP-HRP Bundle | sc-550386 | 200 µg Ab; 40 µg BP | $361.00 |