Edc4 Antibody (F-1): sc-374211
- Edc4 Antibody (F-1) is a mouse monoclonal IgG2b κ, cited in 6 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 457-491 within an internal region of Edc4 of human origin
- recommended for detection of Edc4 of mouse, rat, human and origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Edc4 Antibody (F-1) for WB applications. This reagent is now offered in a bundle with Edc4 Antibody (F-1) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Edc4 Antibody (F-1) is a mouse monoclonal IgG2b antibody that detects Edc4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Edc4, also known as enhancer of mRNA decapping 4, plays a pivotal role in regulating mRNA decay, a crucial process for maintaining cellular homeostasis and gene expression. This 1,401 amino acid protein belongs to the WD repeat EDC4 family and is integral to the mRNA decapping complex, which includes hDcp1a, hDcp2a, RCK, and Edc3. Edc4′s localization to processing bodies (P-bodies) and cytoplasm is essential for mRNA degradation, while a nuclear localization sequence enables nuclear entry, highlighting versatility in cellular processes. Notably, Edc4 undergoes phosphorylation in response to DNA damage, which may influence activity and interactions within the mRNA decay pathway. Edc4 exists in two alternatively spliced isoforms, providing further complexity to regulatory roles, and is encoded by a gene located on human chromosome 16q22.1. With critical involvement in mRNA metabolism, Edc4 serves as a significant target for research into gene regulation and cellular stress responses.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Edc4 Antibody (F-1) | sc-374211 | 200 µg/ml | $322.00 | |||
Edc4 Antibody (F-1): m-IgGκ BP-HRP Bundle | sc-535420 | 200 µg Ab; 40 µg BP | $361.00 | |||
Edc4 (F-1) Neutralizing Peptide | sc-374211 P | 100 µg/0.5 ml | $69.00 |