EB3 Antibody (7): sc-136405

EB3 Antibody (7) is a mouse monoclonal IgG1 kappa light chain antibody that detects EB3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-EB3 antibody (7) is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP) conjugates, providing versatility for different experimental needs. EB3 (7) antibody recognizes a protein that plays a crucial role in regulating microtubule dynamics, essential for various cellular processes such as mitosis, intracellular transport, and cell signaling. EB3 monoclonal antibody (7) targets a protein that binds to growing microtubule ends, influencing cytoskeleton stability and organization, thereby impacting cell shape and motility. This function is particularly important in neuronal development and function, as well as in cancer progression, where abnormal microtubule dynamics can lead to uncontrolled cell proliferation and metastasis. EB3 (7) monoclonal antibody detects a protein predominantly expressed in the central nervous system that preferentially associates with adenomatous polyposis coli-like protein (APCL), further indicating involvement in cellular signaling pathways critical for maintaining normal cellular functions and preventing tumorigenesis.

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EB3 Antibody (7) References:

1. Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas.  |  Cottrell, S., et al. 1992. Lancet. 340: 626-30. PMID: 1355210
2. APC binds to the novel protein EB1.  |  Su, LK., et al. 1995. Cancer Res. 55: 2972-7. PMID: 7606712
3. Inactivation of both APC alleles in human and mouse tumors.  |  Levy, DB., et al. 1994. Cancer Res. 54: 5953-8. PMID: 7954428
4. The APC gene product in normal and tumor cells.  |  Smith, KJ., et al. 1993. Proc Natl Acad Sci U S A. 90: 2846-50. PMID: 8385345
5. Somatic mutations of the APC gene in sporadic hepatoblastomas.  |  Oda, H., et al. 1996. Cancer Res. 56: 3320-3. PMID: 8764128
6. Molecular biology of colorectal cancer.  |  Gryfe, R., et al. 1997. Curr Probl Cancer. 21: 233-300. PMID: 9438104

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-EB3 Antibody (7) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-EB3 Antibody (7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

EB3 Antibody (7) Specifications

Alternate Product Name: EB3

Product Clone Name: 7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 131-222

Epitope Target: EB3

Epitope Species: human

Product Reactivity/Detection: EB3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for EB3 Antibody (7): AC: Agarose, HRP: Horseradish Peroxidase