Molecular structure of E7820, CAS Number: 289483-69-8
E7820 (CAS 289483-69-8)
Alternate Names:
3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)-benzenesulfonamide
CAS Number:
289483-69-8
Molecular Weight:
336.4
Molecular Formula:
C17H12N4O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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E7820 (CAS 289483-69-8) References
- Sulfonamide derivative, E7820, is a unique angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. | Funahashi, Y., et al. 2002. Cancer Res. 62: 6116-23. PMID: 12414636
- An angiogenesis inhibitor E7820 shows broad-spectrum tumor growth inhibition in a xenograft model: possible value of integrin alpha2 on platelets as a biological marker. | Semba, T., et al. 2004. Clin Cancer Res. 10: 1430-8. PMID: 14977846
- Enhanced anti-angiogenic effect of E7820 in combination with erlotinib in epidermal growth factor receptor-tyrosine kinase inhibitor-resistant non-small-cell lung cancer xenograft models. | Ito, K., et al. 2014. Cancer Sci. 105: 1023-31. PMID: 24841832
- Selective degradation of splicing factor CAPERα by anticancer sulfonamides. | Uehara, T., et al. 2017. Nat Chem Biol. 13: 675-680. PMID: 28437394
- Collagen facilitates the colorectal cancer stemness and metastasis through an integrin/PI3K/AKT/Snail signaling pathway. | Wu, X., et al. 2019. Biomed Pharmacother. 114: 108708. PMID: 30913493
- Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15. | Faust, TB., et al. 2020. Nat Chem Biol. 16: 7-14. PMID: 31686031
- Structural Basis and Kinetic Pathway of RBM39 Recruitment to DCAF15 by a Sulfonamide Molecular Glue E7820. | Du, X., et al. 2019. Structure. 27: 1625-1633.e3. PMID: 31693911
- The small-molecule protein ligand interface stabiliser E7820 induces differential cell line specific responses of integrin α2 expression. | Hülskamp, MD., et al. 2021. BMC Cancer. 21: 571. PMID: 34006252
- Role of integrin α2 in methotrexate-induced epithelial-mesenchymal transition in alveolar epithelial A549 cells. | Kawami, M., et al. 2022. Toxicol Res. 38: 449-458. PMID: 36277370
- A molecular glue RBM39-degrader induces synthetic lethality in cancer cells with homologous recombination repair deficiency. | Kohsaka, S., et al. 2024. NPJ Precis Oncol. 8: 117. PMID: 38789724
Inhibitor of:
DCAF17, Fibronectin, hnRNP A2/B1, Integrin α1, Integrin α2, Integrin α3, Integrin α5, Integrin α6, Integrin α8, Integrin β1, Integrin alpha IIb, Pinch-1, SC35, Sm D3, TRAF3, and Vitronectin.Activator of:
Integrin α9, and Integrin β6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
E7820, 10 mg | sc-507333 | 10 mg | $102.00 |