E6BP Antibody (30): sc-293069

E6BP Antibody (30) is a mouse monoclonal IgG2a kappa light chain antibody that detects E6BP in human, mouse, and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). E6BP Antibody (30) is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP). E6BP, also known as reticulocalbin 2, is a 320 amino acid protein that plays a crucial role in calcium binding and signaling within cells. E6BP belongs to the CREC family and is encoded by a gene located on human chromosome 15q23. E6BP exhibits a high affinity for calcium ions and is involved in the interaction with the presynaptic snake venom toxin, taipoxin, which may influence activation and internalization. E6BP is predominantly expressed in the brain, cerebellum, heart, liver, kidney, skeletal muscle, and testis, highlighting importance in various physiological processes. E6BP shares structural homology with other EF-hand proteins, such as calmodulin and calbindin, particularly in the EF-hand domain, which is essential for calcium binding. Limited abundance suggests E6BP is not primarily a calcium storage protein, but rather plays a specialized role in calcium signaling pathways. The unique properties of E6BP, including binding motif shared with E6-AP, which interacts with cancer-related papillomaviral E6 proteins, underscore potential significance in both normal cellular functions and disease mechanisms.

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E6BP Antibody (30) References:

1. Solution structure determination and mutational analysis of the papillomavirus E6 interacting peptide of E6AP.  |  Be, X., et al. 2001. Biochemistry. 40: 1293-9. PMID: 11170455
2. Inhibition of serum- and calcium-induced terminal differentiation of human keratinocytes by HPV 16 E6: study of the association with p53 degradation, inhibition of p53 transactivation, and binding to E6BP.  |  Sherman, L., et al. 2002. Virology. 292: 309-20. PMID: 11878933
3. Overexpression of RCN1 and RCN2, rice TERMINAL FLOWER 1/CENTRORADIALIS homologs, confers delay of phase transition and altered panicle morphology in rice.  |  Nakagawa, M., et al. 2002. Plant J. 29: 743-50. PMID: 12148532
4. Kinetic analysis of the interactions of human papillomavirus E6 oncoproteins with the ubiquitin ligase E6AP using surface plasmon resonance.  |  Zanier, K., et al. 2005. J Mol Biol. 349: 401-12. PMID: 15890204
5. Inhibition of papillomavirus protein function in cervical cancer cells by intrabody targeting.  |  Griffin, H., et al. 2006. J Mol Biol. 355: 360-78. PMID: 16324714
6. HPV16 E6 natural variants exhibit different activities in functional assays relevant to the carcinogenic potential of E6.  |  Lichtig, H., et al. 2006. Virology. 350: 216-27. PMID: 16519914
7. Novel reticular calcium binding protein is purified on taipoxin columns.  |  Dodds, D., et al. 1995. J Neurochem. 64: 2339-44. PMID: 7722520

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-E6BP Antibody (30) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-E6BP Antibody (30) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

E6BP Antibody (30) Specifications

Alternate Product Name: E6BP

Product Clone Name: 30

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 27-146

Epitope Target: reticulocalbin-2

Epitope Species: rat

Product Reactivity/Detection: E6BP of human origin and reticulocalbin-2 of mouse and rat origin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for E6BP Antibody (30): AC: Agarose, HRP: Horseradish Peroxidase, X: TransCruz Reagent