E3BP Antibody (F-8): sc-393449

E3BP Antibody (F-8) is a mouse monoclonal IgG1 antibody that detects E3BP in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). E3BP, also known as PDHX (Pyruvate dehydrogenase protein X component) and Lipoyl-containing pyruvate dehydrogenase complex component X, is a crucial 501 amino acid mitochondrial protein that plays a vital role in the proper functioning of the pyruvate dehydrogenase (PDH) complex. This complex serves as the primary link between glycolysis and the tricarboxylic acid (TCA) cycle by catalyzing the irreversible conversion of pyruvate into acetyl-CoA, a key metabolic intermediate. E3BP functions as an anchor for the E3 component to the E2 core of the PDH complex, a critical interaction necessary for maintaining the integrity and functionality of the PDH complex. Deficiencies in E3BP can lead to severe metabolic disorders, including lactic acidosis and developmental delays, underscoring E3BP′s essential role in cellular metabolism and energy production. Anti-E3BP antibody (F-8) serves as an invaluable tool for researchers studying metabolic pathways and related disorders, providing insights into the molecular mechanisms underlying E3BP function and its implications in health and disease.

The preferred E3BP antibody is E3BP Antibody (H-6): sc-377255.