E2F-8 Antibody (9): sc-130313
- E2F-8 Antibody (9) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against recombinant E2F-8 of human origin
- recommended for detection of E2F-8 of human origin by WB, IP and ELISA
- m-IgG1 BP-HRP is the preferred secondary detection reagent for E2F-8 Antibody (9) for WB applications. This reagent is now offered in a bundle with E2F-8 Antibody (9) (see ordering information below).
E2F-8 Antibody (9) is a mouse monoclonal IgG1 antibody that detects E2F-8 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). E2F-8 is a crucial nuclear protein composed of 867 amino acids, featuring two DNA-binding domains, and is part of a larger family of transcription factors that includes E2F-1 through E2F-7. E2F-8 plays a significant role in regulating gene expression necessary for cell cycle progression by binding to the E2 recognition site, 5′-TTTC[CG]CGC-3′, which inhibits E2F-dependent transcription. E2F-8′s importance extends beyond transcriptional regulation; E2F-8 exists as a homodimer or can form heterodimers with E2F-7, thereby influencing various cellular processes. The gene encoding E2F-8 is located on human chromosome 11, a region that is home to over 1,400 genes and accounts for nearly 4% of the human genome. Notably, chromosome 11 is associated with several genetic disorders, including Jervell and Lange-Nielsen syndrome and Jacobsen syndrome, highlighting the critical nature of the genes it harbors. Anti-E2F-8 antibody (9) is an essential tool for researchers investigating the intricate mechanisms of cell cycle regulation and the implications of E2F family proteins in human health and disease.
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E2F-8 Antibody (9) References:
- E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7. | Logan, N., et al. 2005. Oncogene. 24: 5000-4. PMID: 15897886
- Expression of the E2F family of transcription factors and its clinical relevance in ovarian cancer. | Reimer, D., et al. 2006. Ann N Y Acad Sci. 1091: 270-81. PMID: 17341621
- E2F8 as a Novel Therapeutic Target for Lung Cancer. | Park, SA., et al. 2015. J Natl Cancer Inst. 107: PMID: 26089541
- E2F8 is a Potential Therapeutic Target for Hepatocellular Carcinoma. | Lv, Y., et al. 2017. J Cancer. 8: 1205-1213. PMID: 28607595
- The role of E2F8 in the human placenta. | Mizuno, M., et al. 2019. Mol Med Rep. 19: 293-301. PMID: 30387815
- E2F8 regulates the proliferation and invasion through epithelial-mesenchymal transition in cervical cancer. | Kim, LK., et al. 2020. Int J Biol Sci. 16: 320-329. PMID: 31929759
- E2F8 Induces Cell Proliferation and Invasion through the Epithelial-Mesenchymal Transition and Notch Signaling Pathways in Ovarian Cancer. | Eoh, KJ., et al. 2020. Int J Mol Sci. 21: PMID: 32823614
- Emerging role of E2F8 in human cancer. | Lee, DY., et al. 2023. Biochim Biophys Acta Mol Basis Dis. 1869: 166745. PMID: 37164180
- E2F8-CENPL pathway contributes to homologous recombination repair and chemoresistance in breast cancer. | Wang, S., et al. 2024. Cell Signal. 118: 111151. PMID: 38522807
- ENO1 promotes trophoblast invasion regulated by E2F8 in recurrent miscarriage. | Liu, Z., et al. 2024. FASEB J. 38: e23631. PMID: 38661062
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
E2F-8 Antibody (9) | sc-130313 | 200 µg/ml | $322.00 | |||
E2F-8 Antibody (9): m-IgG1 BP-HRP Bundle | sc-542636 | 200 µg Ab; 20 µg BP | $361.00 |