E2F-3 Antibody (PG37): sc-69684
- E2F-3 Antibody (PG37) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
- raised against recombinant E2F-3 of human origin
- recommended for detection of E2F-3 of mouse, rat and human origin by WB and IP
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for E2F-3 Antibody (PG37) for WB applications. These reagents are now offered in bundles with E2F-3 Antibody (PG37) (see ordering information below).
E2F-3 Antibody (PG37) is a mouse monoclonal IgG2a antibody that detects E2F-3 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). E2F-3 plays a crucial role in regulating the cell cycle, particularly in the transition from G1 phase to S phase, where DNA synthesis occurs. This regulation is vital for proper cell proliferation and differentiation, as dysregulation of E2F-3 can lead to uncontrolled cell growth and is often implicated in various cancers. E2F-3 is primarily located in the nucleus, where E2F-3 binds to specific DNA sequences to activate transcription of genes necessary for cell cycle progression. Understanding E2F-3 localization is important because nuclear presence is essential for function as a transcription factor, and any aberrations in localization can disrupt normal cell cycle regulation. E2F-3 interacts with other members of the E2F family and forms complexes with DP-1 protein, which enhances transcriptional activity. The E2F family, including E2F-1, E2F-2, and others, collectively regulates a network of genes critical for cell cycle control, making E2F-3 a key player in maintaining cellular homeostasis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
E2F-3 Antibody (PG37) References:
- E2f3 is critical for normal cellular proliferation. | Humbert, PO., et al. 2000. Genes Dev. 14: 690-703. PMID: 10733529
- Pumilio facilitates miRNA regulation of the E2F3 oncogene. | Miles, WO., et al. 2012. Genes Dev. 26: 356-68. PMID: 22345517
- The role of miR-210, E2F3 and ephrin A3 in angiosarcoma cell proliferation. | Nakashima, S., et al. 2017. Eur J Dermatol. 27: 464-471. PMID: 28739548
- An Rb family-independent E2F3 transcription factor variant impairs STAT5 signaling and mammary gland remodeling during pregnancy in mice. | Liao, Y. and Du, W. 2018. J Biol Chem. 293: 3156-3167. PMID: 29330306
- Stem-Like Signature Predicting Disease Progression in Early Stage Bladder Cancer. The Role of E2F3 and SOX4. | Bellmunt, J. 2018. Biomedicines. 6: PMID: 30072631
- miR-221 promotes lens epithelial cells apoptosis through interacting with SIRT1 and E2F3. | Gong, W., et al. 2019. Chem Biol Interact. 306: 39-46. PMID: 30926320
- Critical Roles of E2F3 in Growth and Musculo-skeletal Phenotype in Mice. | Kim, HR., et al. 2019. Int J Med Sci. 16: 1557-1563. PMID: 31839743
- MiR-363 restrain the proliferation, migration and invasion of colorectal carcinoma cell by targeting E2F3. | Yang, W., et al. 2023. J Cancer. 14: 1362-1370. PMID: 37283793
- MiR-210-3p enhances intermittent hypoxia-induced tumor progression via inhibition of E2F3. | Zhang, XB., et al. 2024. Sleep Breath. 28: 607-617. PMID: 37775619
- PA28γ coordinates the cross-talk between cancer-associated fibroblasts and tumor cells to promote OSCC progression via HDAC1/E2F3/IGF2 signaling. | Li, Z., et al. 2024. Cancer Lett. 594: 216962. PMID: 38768680
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
E2F-3 Antibody (PG37) | sc-69684 | 200 µg/ml | $322.00 | |||
E2F-3 Antibody (PG37): m-IgG Fc BP-HRP Bundle | sc-539219 | 200 µg Ab; 10 µg BP | $361.00 | |||
E2F-3 Antibody (PG37): m-IgG2a BP-HRP Bundle | sc-546684 | 200 µg Ab; 10 µg BP | $361.00 |