E2F-3 Antibody (PG14): sc-69683
- E2F-3 Antibody (PG14) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
- raised against recombinant E2F-3 of human origin
- recommended for detection of E2F-3 of mouse, rat and human origin by WB and IP
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for E2F-3 Antibody (PG14) for WB applications. These reagents are now offered in bundles with E2F-3 Antibody (PG14) (see ordering information below).
E2F-3 Antibody (PG14) is a mouse monoclonal IgG2a antibody that detects E2F-3 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). E2F-3 plays a crucial role in the regulation of the cell cycle, particularly in the transition from the G1 phase to the S phase, where DNA synthesis occurs. E2F-3 is primarily located in the nucleus, where E2F-3 functions as a transcription factor that activates genes necessary for cell cycle progression. The importance of E2F-3′s nuclear localization lies in its ability to regulate the expression of target genes that are essential for cell proliferation and differentiation. Dysregulation of E2F-3 can lead to uncontrolled cell growth and has been implicated in various cancers, making E2F-3 a significant focus of research in cancer biology. Anti-E2F-3 antibody (PG14) is an invaluable tool for studying the mechanisms of cell cycle regulation and the potential therapeutic targets for cancer treatment.
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E2F-3 Antibody (PG14) References:
- Curtailing overexpression of E2F3 in breast cancer using siRNA (E2F3)-based gene silencing. | Vimala, K., et al. 2012. Arch Med Res. 43: 415-22. PMID: 22960857
- E2f3 in tumor macrophages promotes lung metastasis. | Trikha, P., et al. 2016. Oncogene. 35: 3636-46. PMID: 26549026
- MicroRNA-770-5p contributes to podocyte injury via targeting E2F3 in diabetic nephropathy. | Guo, J., et al. 2020. Braz J Med Biol Res. 53: e9360. PMID: 32696822
- Circ-E2F3 acts as a ceRNA for miR-204-5p to promote proliferation, metastasis and apoptosis inhibition in retinoblastoma by regulating ROCK1 expression. | Huang, Y., et al. 2021. Exp Mol Pathol. 120: 104637. PMID: 33844975
- Matrix stiffness modulates hepatic stellate cell activation into tumor-promoting myofibroblasts via E2F3-dependent signaling and regulates malignant progression. | Liu, Z., et al. 2021. Cell Death Dis. 12: 1134. PMID: 34873170
- rtcisE2F promotes the self-renewal and metastasis of liver tumor-initiating cells via N6-methyladenosine-dependent E2F3/E2F6 mRNA stability. | Chen, Z., et al. 2022. Sci China Life Sci. 65: 1840-1854. PMID: 35266112
- CircKRT14 upregulates E2F3 by interacting with miR-1256 to act as an oncogenic factor in esophageal cancer. | Guan, X., et al. 2023. Hum Exp Toxicol. 42: 9603271231155093. PMID: 36738282
- CDK4-E2F3 signals enhance oxidative skeletal muscle fiber numbers and function to affect myogenesis and metabolism. | Bahn, YJ., et al. 2023. J Clin Invest. 133: PMID: 37395281
- E2F-3 accumulation is regulated by polypeptide stability. | Flores, AM., et al. 1998. Oncogene. 16: 1289-98. PMID: 9546430
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
E2F-3 Antibody (PG14) | sc-69683 | 200 µg/ml | $322.00 | |||
E2F-3 Antibody (PG14): m-IgG Fc BP-HRP Bundle | sc-539218 | 200 µg Ab; 10 µg BP | $361.00 | |||
E2F-3 Antibody (PG14): m-IgG2a BP-HRP Bundle | sc-546683 | 200 µg Ab; 10 µg BP | $361.00 |