E2F-2 Antibody (A-6): sc-515402

E2F-2 Antibody (A-6) is a mouse monoclonal IgG2a antibody that detects E2F-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). E2F-2 plays a crucial role in regulating the cell cycle, particularly in the transition from G1 phase to S phase, by controlling the expression of genes necessary for DNA synthesis and cell proliferation. This regulation is vital for maintaining proper cell growth and division, as dysregulation of E2F-2 can lead to uncontrolled cell proliferation and is often implicated in various cancers. E2F-2 is primarily located in the nucleus, where E2F-2 forms complexes with other proteins, including retinoblastoma protein (Rb) and DP-1, to activate or repress target gene transcription. The interaction between E2F-2 and Rb is particularly significant, as this interaction highlights the tumor suppressor function of Rb in cell cycle control. E2F-2′s ability to form heterodimers with DP-1 enhances transcriptional activity, making E2F-2 a key player in the regulation of genes that drive cell cycle progression. Anti-E2F-2 antibody (A-6) enables researchers to gain valuable insights into the mechanisms of cell cycle regulation and the potential implications of E2F-2 in oncogenesis.

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E2F-2 Antibody (A-6) References:

1. Effect of overexpressing the transcription factor E2F2 on cell cycle progression in rabbit corneal endothelial cells.  |  Joyce, NC., et al. 2004. Invest Ophthalmol Vis Sci. 45: 1340-8. PMID: 15111587
2. E2F2 represses cell cycle regulators to maintain quiescence.  |  Infante, A., et al. 2008. Cell Cycle. 7: 3915-27. PMID: 19066456
3. Regulation of vascular contractility and blood pressure by the E2F2 transcription factor.  |  Zhou, J., et al. 2009. Circulation. 120: 1213-21. PMID: 19752322
4. E2f2 induces cone photoreceptor apoptosis independent of E2f1 and E2f3.  |  Chen, D., et al. 2013. Cell Death Differ. 20: 931-40. PMID: 23558950
5. Low E2F2 activity is associated with high genomic instability and PARPi resistance.  |  Rennhack, JP. and Andrechek, ER. 2020. Sci Rep. 10: 17948. PMID: 33087787
6. Hsa-miR-155 regulates the cell cycle and barrier function of corneal endothelial cells through E2F2.  |  Yuan, S., et al. 2021. Am J Transl Res. 13: 1505-1515. PMID: 33841674
7. The RNA-Binding Protein NELFE Promotes Gastric Cancer Growth and Metastasis Through E2F2.  |  Chen, C., et al. 2021. Front Oncol. 11: 677111. PMID: 34295816
8. MicroRNA-144-3p Represses the Growth and EMT of Thyroid Cancer via the E2F2/TNIK Axis in Cells and Male BALB/c Nude Mice.  |  Yi, D., et al. 2022. Endocrinology. 163: PMID: 35579981
9. ZMIZ1 enhances ERα-dependent expression of E2F2 in breast cancer.  |  Zhao, W., et al. 2024. J Mol Endocrinol. 73: PMID: 38564418
10. A cell cycle regulator, E2F2, and glucocorticoid receptor cooperatively transactivate the bovine alphaherpesvirus 1 immediate early transcription unit 1 promoter.  |  El-Mayet, FS. and Jones, C. 2024. J Virol. 98: e0042324. PMID: 38771044

The preferred E2F-2 antibody is E2F-2 Antibody (TFE-25): sc-9967.