E-Selectin/CD62E/SELE Antibody (2Q780): sc-71017

E-Selectin Antibody (2Q780) is a mouse monoclonal IgG1 antibody that detects E-Selectin in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). E-Selectin, also known as ELAM-1 or CD62E, is a crucial adhesion molecule expressed on the surface of endothelial cells, particularly during inflammatory responses. E-Selectin (2Q780) antibody helps identify this protein′s primary function in mediating leukocyte adhesion to vascular endothelium, facilitating migration to sites of inflammation. This process is vital for immune response, allowing immune cells to exit the bloodstream and reach tissues where needed to combat infection or injury. E-Selectin is upregulated in response to pro-inflammatory cytokines, making anti-E-Selectin antibody (2Q780) valuable for studying leukocyte recruitment during inflammatory processes. The interaction of E-Selectin with specific carbohydrates on leukocytes is essential for rolling and adhesion of these cells, a critical step in inflammatory response. E-Selectin monoclonal antibody (2Q780) enables researchers to gain insights into inflammation mechanisms and E-Selectin′s role in various pathological conditions, enhancing understanding of immune responses and potential therapeutic targets.

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E-Selectin/CD62E/SELE Antibody (2Q780) References:

1. Comparison of L-selectin and E-selectin ligand specificities: the L-selectin can bind the E-selectin ligands sialyl Le(x) and sialyl Le(a).  |  Berg, EL., et al. 1992. Biochem Biophys Res Commun. 184: 1048-55. PMID: 1374233
2. E-selectin permits communication between PAF receptors and TRPC channels in human neutrophils.  |  McMeekin, SR., et al. 2006. Blood. 107: 4938-45. PMID: 16514053
3. Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance.  |  Winkler, IG., et al. 2012. Nat Med. 18: 1651-7. PMID: 23086476
4. E-selectin gene (S128R) polymorphism in hemorrhagic stroke: comparison with ischemic stroke.  |  Das, S., et al. 2014. Neurosci Lett. 581: 125-8. PMID: 25168603
5. Effects of tumor necrosis factor and E-selectin on coronary artery flow.  |  Liu, WB., et al. 2017. Eur Rev Med Pharmacol Sci. 21: 1843-1849. PMID: 28485794
6. Changes in E-Selectin Levels Predict Carotid Stenosis Progression after Carotid Artery Stenting.  |  Liu, CH., et al. 2018. Curr Neurovasc Res. 15: 18-25. PMID: 29557748
7. A new way to treat proximal deep venous thrombosis using E-selectin inhibition.  |  Myers, D., et al. 2020. J Vasc Surg Venous Lymphat Disord. 8: 268-278. PMID: 32067728
8. Gangrene, revascularization, and limb function improved with E-selectin/adeno-associated virus gene therapy.  |  Quiroz, HJ., et al. 2021. JVS Vasc Sci. 2: 20-32. PMID: 34617055
9. Computationally guided conversion of the specificity of E-selectin to mimic that of Siglec-8.  |  Wang, X., et al. 2022. Proc Natl Acad Sci U S A. 119: e2117743119. PMID: 36191232
10. The association between alpha4-integrin, P-selectin, and E-selectin in an allergic model of inflammation.  |  Kanwar, S., et al. 1997. J Exp Med. 185: 1077-87. PMID: 9091581

The preferred E-Selectin/CD62E/SELE antibody is E-Selectin/CD62E/SELE Antibody (D-7): sc-137054.