DYNLL1 Antibody (4): sc-136287

DYNLL1 Antibody (4) is a mouse monoclonal IgG1 kappa light chain antibody that detects DYNLL1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-DYNLL1 antibody (4) is available as the non-conjugated format. DYNLL1, also known as Dynein light chain 1, plays a crucial role in cellular transport mechanisms by interacting with the dynein motor complex, which is essential for the movement of cellular cargo along microtubules. DYNLL1 is particularly important in neuronal function, as DYNLL1 has been shown to interact with nitric oxide synthase 1 (NOS1), thereby influencing nitric oxide production, which is vital for processes such as apoptosis, synaptogenesis, and neuronal development. DYNLL1′s ability to destabilize the NOS1 dimer is significant, as dimerization is necessary for NOS1 activity, highlighting DYNLL1′s regulatory role in nitric oxide signaling pathways. Ubiquitously expressed, DYNLL1 shows high expression levels in the testis and moderate levels in the brain, indicating diverse functional implications across different tissues. Additionally, DYNLL1 shares 93% sequence identity with its closely related isoform, DYNLL2, which is involved in myosin Va binding specificity through a unique alternative splicing event.

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DYNLL1 Antibody (4) References:

1. Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes.  |  Fuhrmann, JC., et al. 2002. J Neurosci. 22: 5393-402. PMID: 12097491
2. Cytoplasmic dynein functions as a gear in response to load.  |  Mallik, R., et al. 2004. Nature. 427: 649-52. PMID: 14961123
3. The dynein heavy chain family.  |  Asai, DJ. and Wilkes, DE. 2004. J Eukaryot Microbiol. 51: 23-9. PMID: 15068262
4. The offloading model for dynein function: differential function of motor subunits.  |  Lee, WL., et al. 2005. J Cell Biol. 168: 201-7. PMID: 15642746
5. Genetic analysis of the cytoplasmic dynein subunit families.  |  Pfister, KK., et al. 2006. PLoS Genet. 2: e1. PMID: 16440056
6. The binding of DYNLL2 to myosin Va requires alternatively spliced exon B and stabilizes a portion of the myosin's coiled-coil domain.  |  Wagner, W., et al. 2006. Biochemistry. 45: 11564-77. PMID: 16981716
7. DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells.  |  He, YJ., et al. 2018. Nature. 563: 522-526. PMID: 30464262
8. DYNLL1 is hypomethylated and upregulated in a tumor stage- and grade-dependent manner and associated with increased mortality in hepatocellular carcinoma.  |  Berkel, C. and Cacan, E. 2020. Exp Mol Pathol. 117: 104567. PMID: 33171156
9. Dynamics of the DYNLL1-MRE11 complex regulate DNA end resection and recruitment of Shieldin to DSBs.  |  Swift, ML., et al. 2023. Nat Struct Mol Biol. 30: 1456-1467. PMID: 37696958
10. DYNLL1 accelerates cell cycle via ILF2/CDK4 axis to promote hepatocellular carcinoma development and palbociclib sensitivity.  |  Liu, Y., et al. 2024. Br J Cancer. 131: 243-257. PMID: 38824222
11. Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster.  |  Dick, T., et al. 1996. Mol Cell Biol. 16: 1966-77. PMID: 8628263
12. PIN: an associated protein inhibitor of neuronal nitric oxide synthase.  |  Jaffrey, SR. and Snyder, SH. 1996. Science. 274: 774-7. PMID: 8864115

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DYNLL1 Antibody (4) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-DYNLL1 Antibody (4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DYNLL1 Antibody (4) Specifications

Alternate Product Name: DYNLL1

Product Clone Name: 4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-89

Epitope Target: DYNLL1

Epitope Species: rat

Product Reactivity/Detection: DYNLL1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for DYNLL1 Antibody (4): N/A