Dynein IC1, cytosolic Antibody (G-1): sc-515227

Dynein IC1, cytosolic Antibody (G-1) is a mouse monoclonal IgG3 kappa light chain antibody that detects Dynein IC1, cytosolic of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Dynein IC1, cytosolic antibody (G-1) is available as a non-conjugated format. Dynein proteins play a crucial role in cellular transport mechanisms, functioning as motor proteins that move along microtubules to facilitate the transport of organelles, vesicles, and other cargo within cells. Dynein IC1, cytosolic (G-1) antibody recognizes a complex composed of multiple subunits, including two heavy chains essential for motor activity, and several intermediate and light chains that assist in cargo binding and regulation. This intricate arrangement of subunits converts chemical energy from ATP hydrolysis into mechanical work, enabling microtubule network traversal. The carboxy terminus of Dynein IC1, cytosolic is critical for microtubule interaction, while amino terminal region variability influences regulatory interactions with proteins like dynactin and LIS1, which modulate activity and ensure proper cellular function.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Dynein IC1, cytosolic Antibody (G-1) References:

1. Cytoplasmic dynein functions as a gear in response to load.  |  Mallik, R., et al. 2004. Nature. 427: 649-52. PMID: 14961123
2. Cytoplasmic dynein nucleates microtubules to organize them into radial arrays in vivo.  |  Malikov, V., et al. 2004. Mol Biol Cell. 15: 2742-9. PMID: 15047865
3. The dynein heavy chain family.  |  Asai, DJ. and Wilkes, DE. 2004. J Eukaryot Microbiol. 51: 23-9. PMID: 15068262
4. High speed sliding of axonemal microtubules produced by outer arm dynein.  |  Seetharam, RN. and Satir, P. 2005. Cell Motil Cytoskeleton. 60: 96-103. PMID: 15605357
5. The offloading model for dynein function: differential function of motor subunits.  |  Lee, WL., et al. 2005. J Cell Biol. 168: 201-7. PMID: 15642746
6. Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments.  |  He, Y., et al. 2005. J Cell Biol. 168: 697-703. PMID: 15728192
7. NudEL targets dynein to microtubule ends through LIS1.  |  Li, J., et al. 2005. Nat Cell Biol. 7: 686-90. PMID: 15965467
8. Cytoplasmic dynein nomenclature.  |  Pfister, KK., et al. 2005. J Cell Biol. 171: 411-3. PMID: 16260502
9. Dynein motility: four heads are better than two.  |  McGrath, JL. 2005. Curr Biol. 15: R970-2. PMID: 16332531
10. Genetic analysis of the cytoplasmic dynein subunit families.  |  Pfister, KK., et al. 2006. PLoS Genet. 2: e1. PMID: 16440056
11. Circovirus transport proceeds via direct interaction of the cytoplasmic dynein IC1 subunit with the viral capsid protein.  |  Cao, J., et al. 2015. J Virol. 89: 2777-91. PMID: 25540360
12. [The mechanism of HDAC6 in paraquat-induced autophagy dysfunction of dopaminergic neurons by mediating aggresome-autophagy-lysosomal pathway].  |  Yan, WG., et al. 2021. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 39: 241-247. PMID: 33910280

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Dynein IC1, cytosolic Antibody (G-1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Dynein IC1, cytosolic Antibody (G-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Dynein IC1, cytosolic Antibody (G-1) Specifications

Alternate Product Name: DYNC1I1

Product Clone Name: G-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 61-90

Epitope Target: Dynein IC1, cytosolic

Epitope Species: human

Product Reactivity/Detection: Dynein IC1, cytosolic

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Dynein IC1, cytosolic Antibody (G-1): P: Blocking Peptide

The preferred Dynein IC1/2, cytosolic antibody is Dynein IC1/2, cytosolic Antibody (74-1): sc-13524.