Dynein IC1/2, cytosolic Antibody (E-9): sc-166130

Dynein IC1/2, cytosolic Antibody (E-9) is a mouse monoclonal IgG3 antibody that detects Dynein IC1/2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Dynein IC1/2 is a crucial motor protein that plays a vital role in intracellular transport and cellular organization by facilitating the movement of organelles and vesicles along microtubules. The complex structure of Dynein IC1/2, consisting of multiple subunits including heavy, intermediate, and light chains, is essential for function; the heavy chains are responsible for ATP hydrolysis and force generation, while the light chains assist in cargo binding and transport. The intricate assembly of Dynein IC1/2 allows effective interaction with microtubules, enabling the sliding motion necessary for ciliary and flagellar movement, which is critical for various physiological processes such as cell motility and fluid movement across epithelial surfaces. Additionally, the carboxy terminus of Dynein IC1/2 is highly conserved and plays a significant role in microtubule-dependent motility, underscoring the importance of structural integrity for proper cellular function. Anti-Dynein IC1/2 antibody (E-9) is an invaluable tool for researchers studying the dynamics of cellular transport and regulatory mechanisms involving Dynein IC1/2, as well as interactions with other proteins such as dynactin and LIS1, which are essential for activity and function.

The preferred Dynein IC1/2, cytosolic antibody is Dynein IC1/2, cytosolic Antibody (74-1): sc-13524.