Dynactin p150 Antibody (12): sc-135890
- Dynactin p150 Antibody (12) is a mouse monoclonal IgG1 κ Dynactin p150 antibody, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 3-202 of Dynactin p150 of rat origin
- recommended for detection of the p150 isoform of Dynactin 1 of mouse, rat, human and canine origin by WB, IP and IF
- m-IgG1 BP-HRP is the preferred secondary detection reagent for Dynactin p150 Antibody (12) for WB applications. This reagent is now offered in a bundle with Dynactin p150 Antibody (12) (see ordering information below).
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Dynactin p150 Antibody (12) is a mouse monoclonal IgG1 kappa light chain antibody that detects Dynactin p150 protein of mouse, rat, human, and canine origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-Dynactin p150 antibody (12) is available as the non-conjugated format. Dynactin p150, also known as p150-glued, plays a crucial role in the cellular transport system by acting as a key component of the dynactin complex, which is essential for proper functioning of the dynein motor protein. Dynactin p150 is primarily located in the cytoplasm and particularly enriched in neurons, where Dynactin p150 facilitates transport of organelles along microtubules, ensuring distribution of cellular components necessary for neuronal function and health. Interaction between dynactin and dynein is vital for various cellular processes, including organelle transport, formation of mitotic spindle, and cytokinesis, highlighting Dynactin p150′s importance in maintaining cellular organization and function. Dynactin complex is composed of several subunits, including p22, p50, p62, p150, and Arp1, which work together to enhance versatility and efficiency of dynein-driven transport mechanisms.
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Dynactin p150 Antibody (12) References:
- Cytoplasmic dynein and dynactin in cell division and intracellular transport. | Karki, S. and Holzbaur, EL. 1999. Curr Opin Cell Biol. 11: 45-53. PMID: 10047518
- The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain. | Berrueta, L., et al. 1999. Curr Biol. 9: 425-8. PMID: 10226031
- M phase phosphorylation of cytoplasmic dynein intermediate chain and p150(Glued). | Huang, CY., et al. 1999. J Biol Chem. 274: 14262-9. PMID: 10318847
- Cytoplasmic dynein and dynactin as likely candidates for microtubule-dependent apical targeting of pancreatic zymogen granules. | Kraemer, J., et al. 1999. Eur J Cell Biol. 78: 265-77. PMID: 10350215
- The interaction between cytoplasmic dynein and dynactin is required for fast axonal transport. | Waterman-Storer, CM., et al. 1997. Proc Natl Acad Sci U S A. 94: 12180-5. PMID: 9342383
- The role of the dynactin complex in intracellular motility. | Holleran, EA., et al. 1998. Int Rev Cytol. 182: 69-109. PMID: 9522459
- Characterization of the p22 subunit of dynactin reveals the localization of cytoplasmic dynein and dynactin to the midbody of dividing cells. | Karki, S., et al. 1998. J Cell Biol. 142: 1023-34. PMID: 9722614
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dynactin p150 Antibody (12) | sc-135890 | 200 µg/ml | $322.00 | |||
Dynactin p150 Antibody (12): m-IgG1 BP-HRP Bundle | sc-542643 | 200 µg Ab; 20 µg BP | $361.00 |