DUSP8 Antibody (B-9): sc-271250

DUSP8 Antibody (B-9) is a mouse monoclonal IgG3 kappa light chain antibody that detects DUSP8 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). anti-DUSP8 antibody (B-9) is available as the non-conjugated form. DUSP8 plays a crucial role in cellular signaling by acting as a dual specificity phosphatase, selectively dephosphorylating both phosphothreonine and phosphotyrosine residues on mitogen-activated protein kinases (MAPKs). This function is vital as DUSP8 helps regulate MAPK pathway activity, which is essential for various physiological processes, including cell growth, differentiation, and response to stress. DUSP8 is predominantly expressed in the adult brain, heart, and skeletal muscle, and cytoplasmic localization is significant for modulating MAPK signaling in response to stimuli such as nerve growth factor and insulin. Additionally, DUSP8 has been implicated in pathophysiological mechanisms associated with alcohol dependence, highlighting potential as a therapeutic target in related disorders.

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DUSP8 Antibody (B-9) References:

1. Dual specificity phosphatases: a gene family for control of MAP kinase function.  |  Camps, M., et al. 2000. FASEB J. 14: 6-16. PMID: 10627275
2. Investigation of DUSP8 and CALCA in alcohol dependence.  |  Hink, RL., et al. 2003. Addict Biol. 8: 305-12. PMID: 13129832
3. hVH-5: a protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase.  |  Martell, KJ., et al. 1995. J Neurochem. 65: 1823-33. PMID: 7561881
4. An emerging family of dual specificity MAP kinase phosphatases.  |  Keyse, SM. 1995. Biochim Biophys Acta. 1265: 152-60. PMID: 7696343
5. Functional studies of dual-specificity phosphatases.  |  Sun, H. 1998. Methods Mol Biol. 84: 307-18. PMID: 9666459

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DUSP8 Antibody (B-9) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-DUSP8 Antibody (B-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DUSP8 Antibody (B-9) Specifications

Alternate Product Name: DUSP8

Product Clone Name: B-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 18-43

Epitope Target: DUSP8

Epitope Species: human

Product Reactivity/Detection: DUSP8

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for DUSP8 Antibody (B-9): P: Blocking Peptide