DUSP12 Antibody (H-11): sc-390760
- DUSP12 Antibody (H-11) is a mouse monoclonal IgG1 κ DUSP12 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 254-340 mapping at the C-terminus of DUSP12 of human origin
- DUSP12 Antibody (H-11) is recommended for detection of DUSP12 of human origin by WB, IP, IF and ELISA
- Anti-DUSP12 Antibody (H-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for DUSP12 Antibody (H-11) for WB applications. These reagents are now offered in bundles with DUSP12 Antibody (H-11) (see ordering information below).
DUSP12 Antibody (H-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects DUSP12 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DUSP12 (H-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DUSP12, also known as dual specificity phosphatase 12 or YVH1, is a 340 amino acid protein that plays a crucial role in cellular signaling by dephosphorylating both phosphothreonine and phosphotyrosine residues within mitogen-activated protein (MAP) kinases. This dual specificity is vital for regulating MAP kinase pathways, which are essential for various cellular processes, including growth, differentiation, and response to stress. DUSP12 expression is induced by numerous growth factors and cellular stresses, allowing DUSP12 to act as a negative regulator of MAP kinase superfamily members, thereby maintaining cellular homeostasis. DUSP12 is predominantly localized in the nucleus and exhibits the highest expression levels in the ovary, testis, spleen, and blood leukocytes. Utilizing zinc as a cofactor, DUSP12 catalyzes the conversion of protein tyrosine phosphate to protein tyrosine and free phosphate, highlighting DUSP12′s importance in modulating cellular proliferation and differentiation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DUSP12 Antibody (H-11) References:
- Identification of the human YVH1 protein-tyrosine phosphatase orthologue reveals a novel zinc binding domain essential for in vivo function. | Muda, M., et al. 1999. J Biol Chem. 274: 23991-5. PMID: 10446167
- Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes. | Das, SK., et al. 2006. Diabetes. 55: 2631-9. PMID: 16936214
- The effects of Liuwei Dihuang decoction on the gene expression in the hippocampus of senescence-accelerated mouse. | Cheng, XR., et al. 2007. Fitoterapia. 78: 175-81. PMID: 17337329
- The dual-specificity phosphatase hYVH1 interacts with Hsp70 and prevents heat-shock-induced cell death. | Sharda, PR., et al. 2009. Biochem J. 418: 391-401. PMID: 18973475
- Multiple dual specificity protein tyrosine phosphatases are expressed and regulated differentially in liver cell lines. | Kwak, SP. and Dixon, JE. 1995. J Biol Chem. 270: 1156-60. PMID: 7836374
- Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase. | Groom, LA., et al. 1996. EMBO J. 15: 3621-32. PMID: 8670865
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DUSP12 Antibody (H-11) | sc-390760 | 200 µg/ml | $316.00 | |||
DUSP12 Antibody (H-11): m-IgG Fc BP-HRP Bundle | sc-526190 | 200 µg Ab; 10 µg BP | $354.00 | |||
DUSP12 Antibody (H-11): m-IgG1 BP-HRP Bundle | sc-550727 | 200 µg Ab; 20 µg BP | $354.00 | |||
DUSP12 Antibody (H-11) AC | sc-390760 AC | 500 µg/ml, 25% agarose | $416.00 | |||
DUSP12 Antibody (H-11) HRP | sc-390760 HRP | 200 µg/ml | $316.00 | |||
DUSP12 Antibody (H-11) FITC | sc-390760 FITC | 200 µg/ml | $330.00 | |||
DUSP12 Antibody (H-11) PE | sc-390760 PE | 200 µg/ml | $343.00 | |||
DUSP12 Antibody (H-11) Alexa Fluor® 488 | sc-390760 AF488 | 200 µg/ml | $357.00 | |||
DUSP12 Antibody (H-11) Alexa Fluor® 546 | sc-390760 AF546 | 200 µg/ml | $357.00 | |||
DUSP12 Antibody (H-11) Alexa Fluor® 594 | sc-390760 AF594 | 200 µg/ml | $357.00 | |||
DUSP12 Antibody (H-11) Alexa Fluor® 647 | sc-390760 AF647 | 200 µg/ml | $357.00 | |||
DUSP12 Antibody (H-11) Alexa Fluor® 680 | sc-390760 AF680 | 200 µg/ml | $357.00 | |||
DUSP12 Antibody (H-11) Alexa Fluor® 790 | sc-390760 AF790 | 200 µg/ml | $357.00 |