DTWD1 Antibody (E-5): sc-398408

DTWD1 Antibody (E-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects DTWD1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-DTWD1 antibody (E-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DTWD1, also known as DTW domain-containing protein 1 or MDS009, consists of 304 amino acids and features a unique DXTW motif, classifying DTWD1 within the DTW family. DTWD1 exists in three alternatively spliced isoforms and is encoded by a gene located on human chromosome 15q21.2, a region associated with several genetic disorders, including Angelman and Prader-Willi syndromes, which arise from deletions or mutations in the 15q11-q13 region. DTWD1 plays a crucial role in cellular processes, including the regulation of protein degradation pathways, which are vital for maintaining cellular homeostasis and preventing the accumulation of damaged proteins. Understanding DTWD1 function is essential, as dysregulation of these pathways can lead to various diseases, highlighting anti-DTWD1 antibody (E-5)′s importance in research and diagnostic applications.

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DTWD1 Antibody (E-5) References:

1. Analysis of the DNA sequence and duplication history of human chromosome 15.  |  Zody, MC., et al. 2006. Nature. 440: 671-5. PMID: 16572171
2. Effective gene therapy in an authentic model of Tay-Sachs-related diseases.  |  Cachón-González, MB., et al. 2006. Proc Natl Acad Sci U S A. 103: 10373-10378. PMID: 16801539
3. Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis.  |  Maegawa, GH., et al. 2007. J Biol Chem. 282: 9150-61. PMID: 17237499
4. Molecular epigenetics of Angelman syndrome.  |  Lalande, M. and Calciano, MA. 2007. Cell Mol Life Sci. 64: 947-60. PMID: 17347796
5. [The Prader-Willi syndrome].  |  Diene, G., et al. 2007. Ann Endocrinol (Paris). 68: 129-37. PMID: 17499572
6. Detailed analysis of 15q11-q14 sequence corrects errors and gaps in the public access sequence to fully reveal large segmental duplications at breakpoints for Prader-Willi, Angelman, and inv dup(15) syndromes.  |  Makoff, AJ. and Flomen, RH. 2007. Genome Biol. 8: R114. PMID: 17573966
7. Fibrillin-rich microfibrils: Structural determinants of morphogenetic and homeostatic events.  |  Ramirez, F. and Dietz, HC. 2007. J Cell Physiol. 213: 326-30. PMID: 17708531
8. Extracellular control of TGFbeta signalling in vascular development and disease.  |  ten Dijke, P. and Arthur, HM. 2007. Nat Rev Mol Cell Biol. 8: 857-69. PMID: 17895899
9. Histone deacetylase 3 inhibits new tumor suppressor gene DTWD1 in gastric cancer.  |  Ma, Y., et al. 2015. Am J Cancer Res. 5: 663-73. PMID: 25973305
10. Biogenesis and functions of aminocarboxypropyluridine in tRNA.  |  Takakura, M., et al. 2019. Nat Commun. 10: 5542. PMID: 31804502
11. Inactivating mutations of tumor suppressor genes KLOTHO and DTWD1 in colorectal cancers.  |  Son, HJ., et al. 2020. Pathol Res Pract. 216: 152816. PMID: 31924336
12. Corticosterone-mediated regulation and functions of miR-218-5p in rat brain.  |  Yoshino, Y., et al. 2022. Sci Rep. 12: 194. PMID: 34996981

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DTWD1 Antibody (E-5) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-DTWD1 Antibody (E-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DTWD1 Antibody (E-5) Specifications

Alternate Product Name: DTWD1

Product Clone Name: E-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 27-52

Epitope Target: DTWD1

Epitope Species: human

Product Reactivity/Detection: DTWD1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for DTWD1 Antibody (E-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin