DPP7 Antibody (H-8): sc-390008
- DPP7 Antibody (H-8) is a mouse monoclonal IgG1 provided at 200 µg/ml
- specific for an epitope mapping between amino acids 28-57 at the N-terminus of DPP7 of human origin
- DPP7 Antibody (H-8) is recommended for detection of DPP7 of human origin by WB, IP, IF and ELISA
- Anti-DPP7 Antibody (H-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DPP7 Antibody (H-8). This work is in progress.
QUICK LINKS
DPP7 Antibody (H-8) is a mouse monoclonal IgG1 antibody that detects DPP7 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DPP7 (H-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Dipeptidyl peptidases (DPPs) play a crucial role in regulating the activity of their substrates and have been implicated in several diseases, such as type 2 diabetes, obesity, and cancer. DPP7, also known as dipeptidyl-peptidase 7, DPP2, DPPII, or quiescent cell proline dipeptidase, is primarily located in lysosomes and is expressed in quiescent lymphocytes. DPP7′s ability to cleave Xaa-Pro dipeptides from the N-termini of proteins is vital for the degradation of oligopeptides, which in turn influences various cellular processes. Notably, DPP7 exists as a homodimer through its leucine zipper motif, and DPP7 secretion in response to calcium release is essential for lymphocyte survival, as inhibition of DPP7 leads to apoptosis in quiescent cells. Furthermore, DPP7 interacts with specific voltage-gated potassium channels, potentially altering their expression and biophysical properties, which may also impact T cell function. DPP7′s presence is critical for maintaining immune homeostasis, making DPP7 a significant target for therapeutic interventions in related diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DPP7 Antibody (H-8) References:
- Vesicular localization and characterization of a novel post-proline-cleaving aminodipeptidase, quiescent cell proline dipeptidase. | Chiravuri, M., et al. 2000. J Immunol. 165: 5695-702. PMID: 11067927
- Prolyl peptidases: a serine protease subfamily with high potential for drug discovery. | Rosenblum, JS. and Kozarich, JW. 2003. Curr Opin Chem Biol. 7: 496-504. PMID: 12941425
- Kinetic investigation of human dipeptidyl peptidase II (DPPII)-mediated hydrolysis of dipeptide derivatives and its identification as quiescent cell proline dipeptidase (QPP)/dipeptidyl peptidase 7 (DPP7). | Maes, MB., et al. 2005. Biochem J. 386: 315-24. PMID: 15487984
- Boro-norleucine as a P1 residue for the design of selective and potent DPP7 inhibitors. | Shreder, KR., et al. 2005. Bioorg Med Chem Lett. 15: 4256-60. PMID: 16084722
- Synthesis and structure-activity relationship of N-alkyl Gly-boro-Pro inhibitors of DPP4, FAP, and DPP7. | Hu, Y., et al. 2005. Bioorg Med Chem Lett. 15: 4239-42. PMID: 16085416
- Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor. | Danilova, O., et al. 2007. Bioorg Med Chem Lett. 17: 507-10. PMID: 17055271
- Prolyl peptidases related to dipeptidyl peptidase IV: potential of specific inhibitors in drug discovery. | Van der Veken, P., et al. 2007. Curr Top Med Chem. 7: 621-35. PMID: 17352682
- Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates. | Van der Veken, P., et al. 2007. J Med Chem. 50: 5568-70. PMID: 17958345
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DPP7 Antibody (H-8) | sc-390008 | 200 µg/ml | $316.00 | |||
DPP7 Antibody (H-8) AC | sc-390008 AC | 500 µg/ml, 25% agarose | $416.00 | |||
DPP7 Antibody (H-8) HRP | sc-390008 HRP | 200 µg/ml | $316.00 | |||
DPP7 Antibody (H-8) FITC | sc-390008 FITC | 200 µg/ml | $330.00 | |||
DPP7 Antibody (H-8) PE | sc-390008 PE | 200 µg/ml | $343.00 | |||
DPP7 Antibody (H-8) Alexa Fluor® 488 | sc-390008 AF488 | 200 µg/ml | $357.00 | |||
DPP7 Antibody (H-8) Alexa Fluor® 546 | sc-390008 AF546 | 200 µg/ml | $357.00 | |||
DPP7 Antibody (H-8) Alexa Fluor® 594 | sc-390008 AF594 | 200 µg/ml | $357.00 | |||
DPP7 Antibody (H-8) Alexa Fluor® 647 | sc-390008 AF647 | 200 µg/ml | $357.00 | |||
DPP7 Antibody (H-8) Alexa Fluor® 680 | sc-390008 AF680 | 200 µg/ml | $357.00 | |||
DPP7 Antibody (H-8) Alexa Fluor® 790 | sc-390008 AF790 | 200 µg/ml | $357.00 | |||
DPP7 (H-8) Neutralizing Peptide | sc-390008 P | 100 µg/0.5 ml | $68.00 |