dpp Antibody (A-10): sc-133182

dpp Antibody (A-10) is a mouse monoclonal IgG3 kappa light chain antibody that detects dpp protein of Drosophila melanogaster origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-dpp antibody (A-10) is available as the non-conjugated form, making dpp (A-10) antibody a versatile tool for researchers studying developmental biology. The decapentaplegic (dpp) protein plays a crucial role in the regulation of embryonic development and pattern formation, acting as a secreted signaling molecule within the transforming growth factor-beta (TGFβ) superfamily. dpp protein is essential for the proper formation of various structures during the early stages of Drosophila development, influencing processes such as cell proliferation, differentiation, and tissue patterning. The dpp gene, located on chromosome 2, encodes a 588 amino acid protein that is secreted into the extracellular space, where dpp interacts with specific receptors on target cells to initiate signaling cascades that guide developmental processes. Understanding dpp function is vital, as dpp provides insights into the molecular mechanisms underlying developmental disorders and can inform research in regenerative medicine and cancer biology. With an established role in Drosophila as a model organism, anti-dpp antibody (A-10) is an invaluable resource for scientists exploring the complexities of developmental signaling pathways.

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dpp Antibody (A-10) References:

1. The genome sequence of Drosophila melanogaster.  |  Adams, MD., et al. 2000. Science. 287: 2185-95. PMID: 10731132
2. PP1 binds Sara and negatively regulates Dpp signaling in Drosophila melanogaster.  |  Bennett, D. and Alphey, L. 2002. Nat Genet. 31: 419-23. PMID: 12134149
3. Dpp signaling and the induction of neoplastic tumors by caspase-inhibited apoptotic cells in Drosophila.  |  Pérez-Garijo, A., et al. 2005. Proc Natl Acad Sci U S A. 102: 17664-9. PMID: 16314564
4. Molecular organization of the decapentaplegic gene in Drosophila melanogaster.  |  St Johnston, RD., et al. 1990. Genes Dev. 4: 1114-27. PMID: 2120113
5. Intersex (ix) mutations of Drosophila melanogaster cause nonrandom cell death in genital disc and can induce tumours in genitals in response to decapentaplegic (dpp(disk)) mutations.  |  Chatterjee, RN., et al. 2015. J Genet. 94: 207-20. PMID: 26174668
6. Snoo and Dpp Act as Spatial and Temporal Regulators Respectively of Adult Progenitor Cells in the Drosophila Trachea.  |  Djabrayan, NJ. and Casanova, J. 2016. PLoS Genet. 12: e1005909. PMID: 26942411
7. Boundary Dpp promotes growth of medial and lateral regions of the Drosophila wing.  |  Barrio, L. and Milán, M. 2017. Elife. 6: PMID: 28675372
8. Dpp controls growth and patterning in Drosophila wing precursors through distinct modes of action.  |  Bosch, PS., et al. 2017. Elife. 6: PMID: 28675374
9. The Bric-à-Brac BTB/POZ transcription factors are necessary in niche cells for germline stem cells establishment and homeostasis through control of BMP/DPP signaling in the Drosophila melanogaster ovary.  |  Miscopein Saler, L., et al. 2020. PLoS Genet. 16: e1009128. PMID: 33151937
10. Dpp and Hedgehog promote the glial response to neuronal apoptosis in the developing Drosophila visual system.  |  Velarde, SB., et al. 2021. PLoS Biol. 19: e3001367. PMID: 34379617
11. Deltex modulates Dpp morphogen gradient formation and affects Dpp signaling in Drosophila.  |  Sharma, V., et al. 2022. J Cell Sci. 135: PMID: 35950520
12. Regulation of a decapentaplegic midgut enhancer by homeotic proteins.  |  Manak, JR., et al. 1994. Development. 120: 3605-19. PMID: 7821226

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-dpp Antibody (A-10) has 1 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

dpp Antibody (A-10) Specifications

Alternate Product Name: dpp

Product Clone Name: A-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 480-588

Epitope Target: dpp

Epitope Species: Drosophila melanogaster

Product Reactivity/Detection: dpp

Species Reactivity/Detection: d

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for dpp Antibody (A-10): N/A