DPEP3 Antibody (F-3): sc-515350

DPEP3 Antibody (F-3) is a mouse monoclonal IgM antibody that detects DPEP3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-DPEP3 antibody (F-3) is available as the non-conjugated form. DPEP3, also known as dipeptidase 3 or membrane-bound dipeptidase 3, is a 488 amino acid protein that belongs to the peptidase M19 family and functions as a metalloprotease. DPEP3 is primarily located in the cell membrane of testicular cells, where DPEP3 plays a crucial role in meiosis, essential for sperm cell formation. DPEP3 is vital for male fertility, as DPEP3 is involved in dipeptide hydrolysis and may influence amino acid availability necessary for sperm development. DPEP3 exists as a disulfide-linked homodimer and binds zinc as a cofactor, which is critical for enzymatic activity. Additionally, DPEP3 is inhibited by L-penicillamine and is encoded by a gene that maps to human chromosome 16q22.1, a region associated with various genetic disorders, including giant axonal neuropathy and Rubinstein-Taybi syndrome. DPEP3 presence in the testis highlights DPEP3′s importance in reproductive biology and potential implications in fertility research.

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DPEP3 Antibody (F-3) References:

1. The gene encoding gigaxonin, a new member of the cytoskeletal BTB/kelch repeat family, is mutated in giant axonal neuropathy.  |  Bomont, P., et al. 2000. Nat Genet. 26: 370-4. PMID: 11062483
2. Giant axonal neuropathy (GAN): case report and two novel mutations in the gigaxonin gene.  |  Kuhlenbäumer, G., et al. 2002. Neurology. 58: 1273-6. PMID: 11971098
3. Identification of two additional members of the membrane-bound dipeptidase family.  |  Habib, GM., et al. 2003. FASEB J. 17: 1313-5. PMID: 12738806
4. Genetics of inflammatory bowel disease: progress and prospects.  |  Mathew, CG. and Lewis, CM. 2004. Hum Mol Genet. 13 Spec No 1: R161-8. PMID: 14764625
5. Advances in the genetics of inflammatory bowel disease.  |  Cho, JH. 2004. Curr Gastroenterol Rep. 6: 467-73. PMID: 15527676

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DPEP3 Antibody (F-3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-DPEP3 Antibody (F-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DPEP3 Antibody (F-3) Specifications

Alternate Product Name: DPEP3

Product Clone Name: F-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 46-67

Epitope Target: DPEP3

Epitope Species: human

Product Reactivity/Detection: DPEP3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for DPEP3 Antibody (F-3): P: Blocking Peptide