Dobutamine Hydrochloride is a derivative of dopamine and is used as a β1-adrenergic receptor (β1-AR) agonist. Also shows potential action with β2-AR and α1-AR targets as well. Due to its ability to directly stimulate the sympathetic nervous system, Dobutamine Hydrochloride has been utilized as a sympathomimetic drug.
1. Weber, R. and Tuttle, R. 1977. Rnai: Pharmacological and Biochemical Properties of Drug Substances vol. 1. Goldberg, M.E. ed. Washington, D.C. Am. Pharm. Assoc. Washington, D.C. pp. 109-124
Soluble in water (10 mg/ml, with gentle heating), ethanol (20 mg/ml, with gentle heating), methanol, pyridine, and DMSO (100 mM).
Store at room temperature
527.7° C at 760 mmHg (Predicted)
n20D 1.61 (Predicted)
Plasmodium falciparum: IC50 = 10 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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MertMert, et al. (PubMed ID 26398398) found that dobutamine can ameliorate oxidative stress, thus be beneficial in diabetes induced neuropathic pain in diabetic rats. -SCBT Publication Review
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