Date published: 2026-2-7

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Dobutamine Hydrochloride (CAS 49745-95-1)

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Alternate Names:
Dobutrex
Application:
Dobutamine Hydrochloride is a dopamine derived β1-AR agonist
CAS Number:
49745-95-1
Purity:
≥99%
Molecular Weight:
337.85
Molecular Formula:
C18H23NO3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Dobutamine hydrochloride is often used to simulate physiological conditions in studies involving tissue samples or cell cultures. This makes it a valuable compound for studying certain cellular mechanisms and biochemical responses in controlled environments. In experimental setups, researchers can investigate the intracellular responses and adaptations to external stimuli. Dobutamine hydrochloride acts by binding with adrenergic receptors, which are pivotal in studying the signaling pathways and responses. It is used as a reference standard in the development of new analytical methods in chemical laboratories, ensuring accurate measurement and detection of related substances in complex mixtures.


Dobutamine Hydrochloride (CAS 49745-95-1) References

  1. Effect of a 30-minute infusion of dobutamine hydrochloride on hind limb blood flow and hemodynamics in halothane-anesthetized horses.  |  Raisis, AL., et al. 2000. Am J Vet Res. 61: 1282-8. PMID: 11039562
  2. Particulate and microbial contamination in in-use admixed intravenous infusions.  |  Yorioka, K., et al. 2006. Biol Pharm Bull. 29: 2321-3. PMID: 17077539
  3. Response of hypotensive dogs to dopamine hydrochloride and dobutamine hydrochloride during deep isoflurane anesthesia.  |  Rosati, M., et al. 2007. Am J Vet Res. 68: 483-94. PMID: 17472447
  4. Local dermal hypersensitivity from dobutamine hydrochloride (Dobutrex solution) injection.  |  Wu, CC., et al. 1991. Chest. 99: 1547-8. PMID: 1828022
  5. Hydrogen-ion potential of dobutamine hydrochloride solutions exposed to environmental conditions of neonatal intensive care units.  |  Reis, LL., et al. 2009. J Pediatr (Rio J). 85: 553-6. PMID: 19918623
  6. Stability of dopamine hydrochloride injection in the presence of dobutamine hydrochloride, tolazoline hydrochloride, and theophylline injections.  |  Bhatt-Mehta, V. and Nahata, MC. 1990. J Perinatol. 10: 129-33. PMID: 2358894
  7. Determination of dobutamine hydrochloride by enzymatic catalytic spectrofluorimetry.  |  Tian, FS., et al. 2014. Luminescence. 29: 92-5. PMID: 23616473
  8. Effect of intravenous infusion of dobutamine hydrochloride on the development of early postoperative cognitive dysfunction in elderly patients via inhibiting the release of tumor necrosis factor-α.  |  Sun, D., et al. 2014. Eur J Pharmacol. 741: 150-5. PMID: 25131356
  9. Hydrogen profiles of dobutamine hydrochloride and fentanyl citrate solutions according to intravenous administration systems, temperature, and luminosity conditions.  |  Barros, DP., et al. 2014. J Infus Nurs. 37: 362-8. PMID: 25191819
  10. Possible inhibition mechanism of dobutamine hydrochloride as potent inhibitor for human glucose-6-phosphate dehydrogenase enzyme.  |  Kizilbay, G. and Karaman, M. 2022. J Biomol Struct Dyn. 40: 204-212. PMID: 32835622
  11. Spectrophotometric determination of dobutamine hydrochloride using 3-methylbenzothiazolin-2-one hydrazone.  |  el-Kommos, ME. 1987. Analyst. 112: 101-3. PMID: 3565777
  12. Intermittent dobutamine hydrochloride infusions in outpatients with chronic congestive heart failure.  |  Roffman, DS., et al. 1985. Clin Pharm. 4: 195-9. PMID: 3987220
  13. Stability of dobutamine hydrochloride and verapamil hydrochloride in 0.9% sodium chloride and 5% dextrose injections.  |  Das Gupta, V. and Stewart, KR. 1984. Am J Hosp Pharm. 41: 686-9. PMID: 6720710
  14. Cardiorespiratory responses to an i.v. infusion of dobutamine in the intact anaesthetized dog.  |  Orchard, CH., et al. 1982. Br J Anaesth. 54: 673-9. PMID: 7082527
  15. Temporal effects of an infusion of dobutamine hydrochloride in horses anesthetized with halothane.  |  Young, LE., et al. 1998. Am J Vet Res. 59: 1027-32. PMID: 9706208

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Dobutamine Hydrochloride, 10 mg

sc-203031
10 mg
$67.00

Dobutamine Hydrochloride, 50 mg

sc-203031A
50 mg
$194.00

how to increase its solubility in water

Asked by: Bassel
Thank you for your question . The recommended solubility in water is 10mg/ml with gentle heating.
Answered by: BlakeJ
Date published: 2023-11-07
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Rated 5 out of 5 by from MertMert, et al. (PubMed ID 26398398) found that dobutamine can ameliorate oxidative stress, thus be beneficial in diabetes induced neuropathic pain in diabetic rats. -SCBT Publication Review
Date published: 2015-02-24
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Dobutamine Hydrochloride is rated 5.0 out of 5 by 1.
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