dNT-1 Antibody (F-9): sc-271972

dNT-1 Antibody (F-9) is a mouse monoclonal IgG1 antibody that detects dNT-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). dNT-1, a cytosolic enzyme, plays a crucial role in regulating pyrimidine nucleotide pools, which are essential for DNA synthesis and repair. By maintaining the balance of these nucleotides, dNT-1 ensures proper cellular function and proliferation, making dNT-1 vital for processes such as cell division and response to DNA damage. The human dNT-1 gene is located on chromosome 10q24.2, and dNT-1 dysfunction has been implicated in various diseases, including cancer, where altered nucleotide metabolism can lead to uncontrolled cell growth. Anti-dNT-1 antibody (F-9) provides a reliable tool for researchers studying nucleotide metabolism and its implications in health and disease, allowing for detailed analysis of dNT-1 expression and activity in various biological contexts.

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dNT-1 Antibody (F-9) References:

1. A deoxyribonucleotidase in mitochondria: involvement in regulation of dNTP pools and possible link to genetic disease.  |  Rampazzo, C., et al. 2000. Proc Natl Acad Sci U S A. 97: 8239-44. PMID: 10899995
2. Cytosolic high K(m) 5'-nucleotidase and 5'(3')-deoxyribonucleotidase in substrate cycles involved in nucleotide metabolism.  |  Gazziola, C., et al. 2001. J Biol Chem. 276: 6185-90. PMID: 11083867
3. Mouse cytosolic and mitochondrial deoxyribonucleotidases: cDNA cloning of the mitochondrial enzyme, gene structures, chromosomal mapping and comparison with the human orthologs.  |  Rampazzo, C., et al. 2002. Gene. 294: 109-17. PMID: 12234672
4. Cytosolic and mitochondrial deoxyribonucleotidases: activity with substrate analogs, inhibitors and implications for therapy.  |  Mazzon, C., et al. 2003. Biochem Pharmacol. 66: 471-9. PMID: 12907246
5. Aerobic and anaerobic toluene degradation by a newly isolated denitrifying bacterium, Thauera sp. strain DNT-1.  |  Shinoda, Y., et al. 2004. Appl Environ Microbiol. 70: 1385-92. PMID: 15006757
6. Hepatitis C virus non-structural protein 3 interacts with cytosolic 5'(3')-deoxyribonucleotidase and partially inhibits its activity.  |  Fang, CP., et al. 2013. PLoS One. 8: e68736. PMID: 23874742
7. Backbone resonance assignments of human cytosolic dNT-1 nucleotidase.  |  Hnízda, A., et al. 2014. Biomol NMR Assign. 8: 425-8. PMID: 24234349
8. Synthesis, Structures, and Properties of BN-Dinaphthothiophenes: Influence of B and N Placement on Photophysical Properties and Aromaticity.  |  Zhang, Q., et al. 2020. J Org Chem. 85: 7877-7883. PMID: 32408747
9. A Novel Method for the Synthesis of MOF-199 for Sensing and Photocatalytic Applications.  |  Garg, D., et al. 2022. J Fluoresc. 32: 1171-1188. PMID: 35347530
10. Abnormal biomarkers predict complex FAS or FADD defects missed by exome sequencing.  |  Rensing-Ehl, A., et al. 2024. J Allergy Clin Immunol. 153: 297-308.e12. PMID: 37979702

The preferred dNT-1 antibody is dNT-1 Antibody (C-10): sc-390041.