DnaJC10 Antibody (66.7): sc-100713
- DnaJC10 Antibody (66.7) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 50 µg/0.5 ml
- raised against recombinant DnaJC10 of human origin
- recommended for detection of DnaJC10 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DnaJC10 Antibody (66.7). This work is in progress.
DnaJC10 Antibody (66.7) is a mouse monoclonal IgG1 antibody that detects DnaJC10 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). DnaJC10, also known as ERdj5 or macrothioredoxin, is a crucial endoplasmic reticulum co-chaperone that plays a significant role in protein folding and translocation across the endoplasmic reticulum membrane. DnaJC10 is essential for maintaining cellular homeostasis, particularly under stress conditions, as anti-DnaJC10 antibody (66.7) assists in the proper folding of nascent polypeptides and the refolding of misfolded proteins. DnaJC10′s interaction with other chaperones, such as HSP70, enhances function in the protein quality control system, which is vital for preventing the accumulation of dysfunctional proteins that can lead to cellular stress and disease. Additionally, DnaJC10 is involved in the regulation of oxidative stress responses, making DnaJC10 an important player in cellular defense mechanisms. With diverse roles in protein management and cellular protection, DnaJC10 is a key target for research into various diseases, including neurodegenerative disorders and cancer, where protein misfolding and aggregation are prevalent.
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DnaJC10 Antibody (66.7) References:
- DNAJC proteins and pathways to parkinsonism. | Roosen, DA., et al. 2019. FEBS J. 286: 3080-3094. PMID: 31120186
- Upregulation of JHDM1D-AS1 protects PDLSCs from H2O2-induced apoptosis by decreasing DNAJC10 via phosphorylation of eIF2α. | Shi, B., et al. 2019. Biochimie. 165: 48-56. PMID: 31276733
- AAV-mediated ERdj5 overexpression protects against P23H rhodopsin toxicity. | Aguilà, M., et al. 2020. Hum Mol Genet. 29: 1310-1318. PMID: 32196553
- DNAJC10 correlates with tumor immune characteristics and predicts the prognosis of glioma patients. | Liu, F., et al. 2022. Biosci Rep. 42: PMID: 34988580
- The centromere-associated protein CENPU promotes cell proliferation, migration, and invasiveness in lung adenocarcinoma. | Lou, Y., et al. 2022. Cancer Lett. 532: 215599. PMID: 35176420
- Loss of ERdj5 exacerbates oxidative stress in mice with alcoholic liver disease via suppressing Nrf2. | Hong, DG., et al. 2022. Free Radic Biol Med. 184: 42-52. PMID: 35390453
- Distinct role of ERp57 and ERdj5 as a disulfide isomerase and reductase during ER protein folding. | Robinson, PJ., et al. 2023. J Cell Sci. 136: PMID: 36655611
- DNAJC10 maintains survival and self-renewal of leukemia stem cells through PERK branch of the unfolded protein response. | Li, M., et al. 2024. Haematologica. 109: 751-764. PMID: 37496439
- Mechanistic characterization of disulfide bond reduction of an ERAD substrate mediated by cooperation between ERdj5 and BiP. | Cai, X., et al. 2023. J Biol Chem. 299: 105274. PMID: 37739037
- MCM8 promotes lung cancer progression through upregulating DNAJC10. | Cao, L., et al. 2024. J Cell Mol Med. 28: e18488. PMID: 39031896
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DnaJC10 Antibody (66.7) | sc-100713 | 50 µg/0.5 ml | $333.00 |