DnaJA2 Antibody (7): sc-136515

DnaJA2 Antibody (7) is a mouse monoclonal IgG1 kappa light chain antibody that detects DnaJA2 protein of mouse, rat, human, and canine origin by western blotting (WB) and immunoprecipitation (IP). Anti-DnaJA2 antibody (7) is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP). The DnaJ family, to which DnaJA2 belongs, is one of the largest chaperone families and is characterized by diverse cellular localization and functions, primarily defined by the presence of the J domain. DnaJA2, also known as HIRA-interacting protein 4 or cell cycle progression restoration gene 3 protein, plays a pivotal role in cellular stress response by acting as a co-chaperone for HSC 70, facilitating proper folding and stabilization of proteins under stress conditions. DnaJA2 is particularly important in cellular homeostasis, helping prevent aggregation of misfolded proteins, which can lead to cellular dysfunction and disease. DnaJA2 contains a CR-type zinc finger, which is crucial for interaction with other proteins and contributes to chaperone activity. DnaJA2′s ability to regulate protein folding and degradation underscores significance in maintaining cellular integrity and function, making DnaJA2 a valuable target for research in various biological and pathological processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

DnaJA2 Antibody (7) References:

1. Analysis of the function of mycobacterial DnaJ proteins by overexpression and microarray profiling.  |  Stewart, GR., et al. 2004. Tuberculosis (Edinb). 84: 180-7. PMID: 15207487
2. The C-terminal (331-376) sequence of Escherichia coli DnaJ is essential for dimerization and chaperone activity: a small angle X-ray scattering study in solution.  |  Shi, YY., et al. 2005. J Biol Chem. 280: 22761-8. PMID: 15849180
3. The diversity of the DnaJ/Hsp40 family, the crucial partners for Hsp70 chaperones.  |  Qiu, XB., et al. 2006. Cell Mol Life Sci. 63: 2560-70. PMID: 16952052
4. The Hsp70 chaperone machines of Escherichia coli: a paradigm for the repartition of chaperone functions.  |  Genevaux, P., et al. 2007. Mol Microbiol. 66: 840-57. PMID: 17919282
5. DnaJ recruits DnaK to protein aggregates.  |  Acebrón, SP., et al. 2008. J Biol Chem. 283: 1381-1390. PMID: 17984091
6. Organization and expression of the dnaJ and dnaK genes of Escherichia coli K12.  |  Saito, H. and Uchida, H. 1978. Mol Gen Genet. 164: 1-8. PMID: 360036
7. Identification of the E. coli dnaJ gene product.  |  Georgopoulos, CP., et al. 1980. Mol Gen Genet. 178: 583-8. PMID: 6446654
8. Levels of DnaK and DnaJ provide tight control of heat shock gene expression and protein repair in Escherichia coli.  |  Tomoyasu, T., et al. 1998. Mol Microbiol. 30: 567-81. PMID: 9822822
9. Interaction of the Hsp70 molecular chaperone, DnaK, with its cochaperone DnaJ.  |  Suh, WC., et al. 1998. Proc Natl Acad Sci U S A. 95: 15223-8. PMID: 9860950

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DnaJA2 Antibody (7) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-DnaJA2 Antibody (7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DnaJA2 Antibody (7) Specifications

Alternate Product Name: DnaJA2

Product Clone Name: 7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 294-412

Epitope Target: DnaJA2

Epitope Species: mouse

Product Reactivity/Detection: DnaJA2

Species Reactivity/Detection: mouse, rat, human, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for DnaJA2 Antibody (7): AC: Agarose, HRP: Horseradish Peroxidase