DNA pol γ Antibody (G-6): sc-390634

DNA pol γ Antibody (G-6) is a mouse monoclonal IgG3 antibody that detects DNA pol gamma protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-DNA pol gamma antibody (G-6) is available as a non-conjugated format, providing researchers with a reliable tool for studying this critical enzyme. DNA pol gamma plays a vital role in the replication of mitochondrial DNA, which is essential for maintaining cellular energy production and overall cellular function. Unlike nuclear DNA, mitochondrial DNA is inherited maternally and is crucial for encoding proteins involved in the electron transport chain, which is responsible for ATP synthesis. Proper functioning of DNA pol gamma is therefore critical, as mutations or deficiencies can lead to mitochondrial diseases, characterized by energy deficits and a range of clinical manifestations. DNA pol gamma is unique among DNA polymerases as the only one specifically required for mitochondrial DNA replication, highlighting DNA pol gamma′s importance in both cellular metabolism and genetic stability.

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DNA pol γ Antibody (G-6) References:

1. Eukaryotic DNA mismatch repair.  |  Kolodner, RD. and Marsischky, GT. 1999. Curr Opin Genet Dev. 9: 89-96. PMID: 10072354
2. A full-length cDNA of hREV3 is predicted to encode DNA polymerase zeta for damage-induced mutagenesis in humans.  |  Lin, W., et al. 1999. Mutat Res. 433: 89-98. PMID: 10102035
3. DNA repair. Variants on a theme.  |  Wood, RD. 1999. Nature. 399: 639-40. PMID: 10385109
4. Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymerase.  |  Sharief, FS., et al. 1999. Genomics. 59: 90-6. PMID: 10395804
5. Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta.  |  Diede, SJ. and Gottschling, DE. 1999. Cell. 99: 723-33. PMID: 10619426
6. Direct, DNA pol-gamma-independent effects of nucleoside reverse transcriptase inhibitors on mitochondrial bioenergetics.  |  Lund, KC. and Wallace, KB. 2004. Cardiovasc Toxicol. 4: 217-28. PMID: 15470270
7. DNA replication. Eukaryotic initiation rites.  |  Li, JJ. and Alberts, BM. 1992. Nature. 357: 114-5. PMID: 1579160
8. Properties of DNA polymerases delta and epsilon, and their roles in eukaryotic DNA replication.  |  Bambara, RA. and Jessee, CB. 1991. Biochim Biophys Acta. 1088: 11-24. PMID: 1846563
9. The Δ133p53 Isoform Reduces Wtp53-induced Stimulation of DNA Pol γ Activity in the Presence and Absence of D4T.  |  Liu, K., et al. 2017. Aging Dis. 8: 228-239. PMID: 28400988
10. Remdesivir triphosphate blocks DNA synthesis and increases exonucleolysis by the replicative mitochondrial DNA polymerase, Pol γ.  |  Ciesielska, EJ., et al. 2021. Mitochondrion. 61: 147-158. PMID: 34619353
11. Ancestral allele of DNA polymerase gamma modifies antiviral tolerance.  |  Kang, Y., et al. 2024. Nature. 628: 844-853. PMID: 38570685
12. Cloning and characterization of the human mitochondrial DNA polymerase, DNA polymerase gamma.  |  Ropp, PA. and Copeland, WC. 1996. Genomics. 36: 449-58. PMID: 8884268

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DNA pol γ Antibody (G-6) has 11 citations in a variety of scientific publications.

Primary antibodies like Anti-DNA pol γ Antibody (G-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DNA pol γ Antibody (G-6) Specifications

Alternate Product Name: DNA pol γ

Product Clone Name: G-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃

Amino Acids: 1193-1221

Epitope Target: DNA pol γ

Epitope Species: human

Product Reactivity/Detection: DNA pol γ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine and bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₃ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for DNA pol γ Antibody (G-6): P: Blocking Peptide