DNA pol ε B Antibody (B-3): sc-376703

DNA pol ε B Antibody (B-3) is a mouse monoclonal IgG3 antibody that detects DNA polymerase epsilon (DNA pol ε) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DNA pol ε plays a crucial role in DNA replication, particularly in the synthesis of the leading strand, ensuring accurate and efficient duplication of the genome. Anti-DNA pol ε antibody (B-3) recognizes a multi-subunit complex, with its catalytic subunit encoded by the POL2 gene, which is essential for maintaining genomic stability. Proper functioning of DNA pol ε is vital, as errors in DNA replication can lead to mutations and genomic instability, which are hallmarks of various diseases, including cancer. DNA pol ε is subject to regulation by cell cycle proteins, which modulate activity in response to cellular needs, highlighting importance in coordinating DNA synthesis with the cell cycle. DNA pol ε B (B-3) antibody serves as an invaluable tool for researchers studying mechanisms of DNA replication and repair, as well as implications of these processes in health and disease.

The preferred DNA pol ε B antibody is DNA pol ε B Antibody (C-9): sc-398582.