Dmp1 Antibody (DMTF5I250): sc-81249
- Dmp1 Antibody (DMTF5I250) is a mouse monoclonal IgG1 κ Dmp1 antibody provided at 100 µg/ml
- raised against a recombinant protein fragment corresponding to an internal region of Dmp1 of human origin
- recommended for detection of Dmp1 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Dmp1 Antibody (DMTF5I250). This work is in progress.
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Dmp1 Antibody (DMTF5I250) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Dmp1 protein of human origin by western blotting (WB) and immunoprecipitation (IP). anti-Dmp1 antibody (DMTF5I250) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important protein. Dmp1, also known as cyclin D binding myb-like transcription factor 1, plays a crucial role in regulating cell cycle progression and transcriptional activation. Dmp1 (DMTF5I250) antibody localizes primarily in the nucleus, where Dmp1 functions as a transcription factor that binds to specific DNA sequences to modulate gene expression. This nuclear localization is vital for controlling the expression of genes involved in cell proliferation and differentiation, making Dmp1 a key player in hematopoiesis and oncogenesis. Dmp1 contains three tandem Myb repeats, which are essential for DNA-binding activity, and has been identified as a substrate for cyclin D-dependent kinases, linking Dmp1 to cell cycle regulation. Understanding Dmp1 function and localization is critical for elucidating its involvement in various cellular processes and potential implications in cancer biology.
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Dmp1 Antibody (DMTF5I250) References:
- Expression of Dmp1 in specific differentiated, nonproliferating cells and its regulation by E2Fs. | Mallakin, A., et al. 2006. Oncogene. 25: 7703-13. PMID: 16878159
- Dmp1 and tumor suppression. | Inoue, K., et al. 2007. Oncogene. 26: 4329-35. PMID: 17237816
- Increase in specific DNA binding by carboxyl truncation suggests a mechanism for activation of Myb. | Ramsay, RG., et al. 1991. Oncogene. 6: 1875-9. PMID: 1923510
- DNA binding activity and transcriptional activator function of the human B-myb protein compared with c-MYB. | Mizuguchi, G., et al. 1990. J Biol Chem. 265: 9280-4. PMID: 2160970
- Delineation of three functional domains of the transcriptional activator encoded by the c-myb protooncogene. | Sakura, H., et al. 1989. Proc Natl Acad Sci U S A. 86: 5758-62. PMID: 2668947
- SNX27 links DGKζ to the control of transcriptional and metabolic programs in T lymphocytes. | Tello-Lafoz, M., et al. 2017. Sci Rep. 7: 16361. PMID: 29180720
- Nucleotide sequence of cDNA clones of the murine myb proto-oncogene. | Gonda, TJ., et al. 1985. EMBO J. 4: 2003-8. PMID: 2998780
- Snx27 Deletion Promotes Recovery From Spinal Cord Injury by Neuroprotection and Reduces Macrophage/Microglia Proliferation. | Zeng, Y., et al. 2018. Front Neurol. 9: 1059. PMID: 30619032
- SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation. | Shi, R., et al. 2021. Cell Biosci. 11: 146. PMID: 34315543
- Expression of myb, myc and fos proto-oncogenes during the differentiation of a murine myeloid leukaemia. | Gonda, TJ. and Metcalf, D. Nature. 310: 249-51. PMID: 6205276
- Constitutive expression of B-myb can bypass p53-induced Waf1/Cip1-mediated G1 arrest. | Lin, D., et al. 1994. Proc Natl Acad Sci U S A. 91: 10079-83. PMID: 7937841
- Detection of proteins that bind to the leucine zipper motif of c-Myb. | Favier, D. and Gonda, TJ. 1994. Oncogene. 9: 305-11. PMID: 8302594
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dmp1 Antibody (DMTF5I250) | sc-81249 | 100 µg/ml | $339.00 |