Anti-DMP-1 Antibody (LFMb-31) is a mouse monoclonal IgG1 (kappa light chain) DMP-1 antibody provided at 200 µg/ml
raised against the last exon in pET15b of DMP-1 of human origin
Anti-DMP-1 Antibody (LFMb-31) is recommended for detection of dentin matrix protein 1 epitope maps to RGD domain of human and monkey origin by WB, IP, IF and IHC(P)
Anti-DMP-1 Antibody (LFMb-31) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
See m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP), our highly recommended recombinant alternative to conventional secondary anti-mouse IgG reagents.
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of DMP-1 (LFMb-31): sc-73633.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
DMP-1 Antibody (LFMb-31) is a high quality monoclonal DMP-1 antibody (also designated DMP-1 antibody) suitable for the detection of the DMP-1 protein of human and monkey origin. DMP-1 Antibody (LFMb-31) is available as both the non-conjugated anti-DMP-1 antibody form, as well as multiple conjugated forms of anti-DMP-1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. DMP-1 (dentin matrix protein-1), also known as dentin matrix acidic phosphoprotein-1, is a member of the small integrin ligand N-linked glycoprotein family. It is important for the mineralization of bone and dentin. DMP-1 is expressed in bone, tooth and hypertrophic cartilage. It is synthesized by preosteoblasts and contains a large number of acidic domains. DMP-1 localizes to the nucleus of undifferentiated osteoblasts where it functions as a transcriptional regulator for osteoblast-specific gene activation and induces osteoblast differentiation. During osteoblast maturation, DMP-1 undergoes a conformational change and becomes phosphorylated by casein kinase II in response to an influx of calcium ions to the nucleus. DMP-1 is then exported to the extracellular matrix (ECM) where it regulates the nucleation of hydroxyapatite and the formation of calcified tissue. DMP-1 is proteolytically processed into N- and C-terminal fragments in the ECM of bone and dentin. The protein has also been identified in bone as a high molecular weight proteoglycan comprised of the N-terminal DMP-1 fragment and chondroitin sulfate.The loss of DMP-1 can result in hypomineralized bone.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Can DMP-1 (LFMb-31): sc-73633 monoclonal antibody be used for double or triple staining, if the other primary antibodies are also raised in mouse?
Asked by: jenni
In this case, we recommend using a directly conjugated mouse monoclonal primary antibody. DMP-1 (LFMb-31): sc-73633 is available conjugated to agarose (sc-73633 AC), 500 µg/0.25 ml agarose in 1 ml, for IP; HRP (sc-73633 HRP), 200 µg/ml, for WB, IHC(P) and ELISA; phycoerythrin (sc-73633 PE), fluorescein (sc-73633 FITC), Alexa Fluor® 488 (sc-73633 AF488) or Alexa Fluor® 647 (sc-73633 AF647), 200 µg/ml, for IF, IHC(P) and FCM
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn