Dlx-2 Antibody (E-7): sc-390468

Dlx-2 Antibody (E-7) is a mouse monoclonal IgM antibody that detects Dlx-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Dlx-2 is a member of the Dlx gene family, which plays a crucial role in the development of the craniofacial skeleton and the differentiation of various tissues, including those within the teeth. Dlx-2 is primarily localized in the nucleus, where Dlx-2 functions as a transcription factor, influencing gene expression patterns essential for proper morphogenesis and histogenesis. Notably, Dlx-2 interacts with other proteins such as Dlx-1 and Dlx-5, which are also involved in similar developmental processes, thereby forming a regulatory network that ensures the correct formation of craniofacial structures. Precise regulation of Dlx-2 and its interactions are vital for normal development, as dysregulation can lead to congenital anomalies and other developmental disorders. With an ability to provide insights into these critical biological processes, anti-Dlx-2 antibody (E-7) is an invaluable tool for researchers studying developmental biology and related fields.

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Dlx-2 Antibody (E-7) References:

1. Biomineralization, life-time of odontogenic cells and differential expression of the two homeobox genes MSX-1 and DLX-2 in transgenic mice.  |  Lézot, F., et al. 2000. J Bone Miner Res. 15: 430-41. PMID: 10750557
2. Pallial and subpallial derivatives in the embryonic chick and mouse telencephalon, traced by the expression of the genes Dlx-2, Emx-1, Nkx-2.1, Pax-6, and Tbr-1.  |  Puelles, L., et al. 2000. J Comp Neurol. 424: 409-38. PMID: 10906711
3. Bone morphogenetic protein-2 (BMP-2) signaling to the Col2alpha1 gene in chondroblasts requires the homeobox gene Dlx-2.  |  Xu, SC., et al. 2001. DNA Cell Biol. 20: 359-65. PMID: 11445007
4. DLX genes as targets of ALL-1: DLX 2,3,4 down-regulation in t(4;11) acute lymphoblastic leukemias.  |  Ferrari, N., et al. 2003. J Leukoc Biol. 74: 302-5. PMID: 12885948
5. The spatial localization of Dlx-2 during tooth development.  |  Thomas, BL., et al. 1995. Connect Tissue Res. 32: 27-34. PMID: 7554927
6. Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain.  |  Qiu, M., et al. 1995. Genes Dev. 9: 2523-38. PMID: 7590232
7. Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries.  |  Bulfone, A., et al. 1993. J Neurosci. 13: 3155-72. PMID: 7687285
8. Differential and overlapping expression domains of Dlx-2 and Dlx-3 suggest distinct roles for Distal-less homeobox genes in craniofacial development.  |  Robinson, GW. and Mahon, KA. 1994. Mech Dev. 48: 199-215. PMID: 7893603
9. The mouse Dlx-2 (Tes-1) gene is expressed in spatially restricted domains of the forebrain, face and limbs in midgestation mouse embryos.  |  Bulfone, A., et al. 1993. Mech Dev. 40: 129-40. PMID: 8098616
10. Mutations of the homeobox genes Dlx-1 and Dlx-2 disrupt the striatal subventricular zone and differentiation of late born striatal neurons.  |  Anderson, SA., et al. 1997. Neuron. 19: 27-37. PMID: 9247261

The preferred Dlx-2 antibody is Dlx-2 Antibody (B-5): sc-393879.