Dipyrone (CAS 68-89-3)
See product citations (5)
QUICK LINKS
Dipyrone, also known as metamizole, is a non-opioid analgesic and antipyretic compound. It operates primarily through its active metabolites, which inhibit the cyclooxygenase (COX) enzymes COX-1 and COX-2 to a lesser extent than traditional NSAIDs, leading to a decrease in the production of prostaglandins. This inhibition is thought to contribute to its analgesic and antipyretic effects. However, dipyrone′s mechanism also involves other less understood pathways that may contribute to its efficacy, including the modulation of cannabinoid and opioid systems, and effects on the L-arginine/nitric oxide pathway. In research applications, dipyrone is of interest not only for its unique pharmacological profile but also for its utility in studying pain mechanisms and fever response in animal models. Its ability to act without significant anti-inflammatory effects makes it useful in experiments designed to parse the roles of pain, inflammation, and fever in physiological and pathological processes, offering insights into how pain is mediated and managed by the body.
Dipyrone (CAS 68-89-3) References
- Opioid tolerance induced by metamizol (dipyrone) microinjections into the periaqueductal grey of rats. | Tortorici, V. and Vanegas, H. 2000. Eur J Neurosci. 12: 4074-80. PMID: 11069604
- Antinociception induced by PAG-microinjected dipyrone (metamizol) in rats: involvement of spinal endogenous opioids. | Hernández, N. and Vanegas, H. 2001. Brain Res. 896: 175-8. PMID: 11277989
- Spectrophotometric multicomponent analysis of a mixture of metamizol, acetaminophen and caffeine in pharmaceutical formulations by two chemometric techniques. | Dinç, E., et al. 2001. J Pharm Biomed Anal. 26: 949-57. PMID: 11600307
- A comparative study of the antipyretic effects of indomethacin and dipyrone in rats. | De Souza, GE., et al. 2002. Inflamm Res. 51: 24-32. PMID: 11852909
- Characterization of the role of physicochemical factors on the hydrolysis of dipyrone. | Ergün, H., et al. 2004. J Pharm Biomed Anal. 35: 479-87. PMID: 15137974
- Different mechanisms underlie the analgesic actions of paracetamol and dipyrone in a rat model of inflammatory pain. | Rezende, RM., et al. 2008. Br J Pharmacol. 153: 760-8. PMID: 18157167
- Photodegradation study of three dipyrone metabolites in various water systems: identification and toxicity of their photodegradation products. | Gómez, MJ., et al. 2008. Water Res. 42: 2698-706. PMID: 18294672
- Depression by morphine and the non-opioid analgesic agents, metamizol (dipyrone), lysine acetylsalicylate, and paracetamol, of activity in rat thalamus neurones evoked by electrical stimulation of nociceptive afferents. | Carlsson, KH., et al. 1988. Pain. 32: 313-326. PMID: 3129687
- A study of the mechanism of action of the mild analgesic dipyrone. | Shimada, SG., et al. 1994. Agents Actions. 41: 188-92. PMID: 7942328
- Analgesic and antiinflammatory effects of dipyrone in rat adjuvant arthritis model. | Tatsuo, MA., et al. 1994. Inflammation. 18: 399-405. PMID: 7982729
- Morphological and biochemical action of dipyrone on rat placenta. | Espiridiäo, S., et al. 1996. Gen Pharmacol. 27: 505-7. PMID: 8723534
- Diminished neuronal damage in the rat brain by late treatment with the antipyretic drug dipyrone or cooling following cerebral ischemia. | Coimbra, C., et al. 1996. Acta Neuropathol. 92: 447-53. PMID: 8922055
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dipyrone, 250 mg | sc-252755B | 250 mg | $20.00 | |||
Dipyrone, 1 g | sc-252755A | 1 g | $32.00 | |||
Dipyrone, 10 g | sc-252755C | 10 g | $61.00 | |||
Dipyrone, 25 g | sc-252755 | 25 g | $112.00 |