DIP2A Antibody (4E6): sc-293390
- DIP2A Antibody (4E6) is a mouse monoclonal IgG2a κ DIP2A antibody provided at 100 µg/ml
- raised against amino acids 107-301 of DIP2A of human origin
- recommended for detection of DIP2A of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DIP2A Antibody (4E6). This work is in progress.
DIP2A Antibody (4E6) is a mouse monoclonal IgG2a kappa light chain antibody that detects the DIP2A protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-DIP2A antibody (4E6) is available as a non-conjugated format. DIP2A, or disco-interacting protein 2 homolog A, is a 1,571 amino acid nuclear protein that plays a crucial role in the development of the nervous system. DIP2A represents one of three human homologs (DIP2A, DIP2B, and DIP2C) of the Drosophila dip2 protein, which is essential for neuronal connections in the visual systems of both larvae and adults. The closest vertebrate homologs to dip2 are the basonuclin genes, and in mice, DIP2 homologs exhibit restricted expression primarily in the brain. This suggests that, akin to the function of Drosophila dip2, vertebrate DIP2 homologs may be integral to nervous system development. DIP2A is expressed ubiquitously, with the highest levels found in the brain, and facilitates signaling throughout the central nervous system by providing positional cues for axon patterning and pathfinding. Notably, four isoforms of DIP2A arise from alternative splicing events, which may contribute to functional diversity and regulatory mechanisms in neuronal development.
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DIP2A Antibody (4E6) References:
- Cloning, genomic organization and expression pattern of a novel Drosophila gene, the disco-interacting protein 2 (dip2), and its murine homolog. | Mukhopadhyay, M., et al. 2002. Gene. 293: 59-65. PMID: 12137943
- A novel double-stranded RNA-binding protein, disco interacting protein 1 (DIP1), contributes to cell fate decisions during Drosophila development. | DeSousa, D., et al. 2003. J Biol Chem. 278: 38040-50. PMID: 12829713
- Characterization of DIP1, a novel nuclear protein in Drosophila melanogaster. | De Felice, B., et al. 2003. Biochem Biophys Res Commun. 307: 224-8. PMID: 12859943
- Hox transcription factor ultrabithorax Ib physically and genetically interacts with disconnected interacting protein 1, a double-stranded RNA-binding protein. | Bondos, SE., et al. 2004. J Biol Chem. 279: 26433-44. PMID: 15039447
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DIP2A Antibody (4E6) | sc-293390 | 100 µg/ml | $322.00 |