DGUOK Antibody (H-2): sc-376463

DGUOK Antibody (H-2) is a mouse monoclonal IgG1 antibody that detects DGUOK in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DGUOK, or deoxyguanosine kinase, is a crucial 277 amino acid protein localized in the mitochondria, where DGUOK plays a vital role in cellular metabolism. DGUOK functions as a homodimer and is highly expressed in various tissues, including the liver, muscle, and brain. DGUOK catalyzes the conversion of deoxyguanosine to dGMP using ATP, which is essential for the phosphorylation of purine deoxyribonucleosides within the mitochondrial matrix. This enzymatic activity is particularly important for maintaining mitochondrial DNA integrity and supporting cellular energy metabolism. DGUOK serves as a significant target in antiviral and chemotherapeutic strategies, highlighting DGUOK′s relevance in therapeutic applications. Notably, defects in the gene encoding DGUOK can lead to hepatocerebral mitochondrial DNA depletion syndrome, a serious condition characterized by reduced mitochondrial DNA copy number, liver failure, and neurological abnormalities. Anti-DGUOK antibody (H-2) is an invaluable tool for researchers studying mitochondrial function and related disorders.

The preferred DGUOK antibody is DGUOK Antibody (H-3): sc-376267.