DGK-ε Antibody (AA9): sc-100372

DGK-ε Antibody (AA9) is a mouse monoclonal IgG3 antibody that detects DGK-epsilon protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-DGK-epsilon antibody (AA9) is available as a non-conjugated format. DGK-epsilon protein plays a crucial role in cellular signaling by phosphorylating diacylglycerol (DAG) to generate phosphatidic acid, both of which are important lipid second messengers involved in various signaling pathways. This enzymatic activity is vital for regulating processes such as cell activation, proliferation, and apoptosis, making DGK-epsilon a significant player in maintaining cellular homeostasis and response to external stimuli. Notably, DGK-epsilon exhibits specificity for arachidonyl-containing diacylglycerol and is predominantly expressed in the testis, suggesting potential involvement in reproductive signaling pathways. The diverse expression patterns and regulatory functions of DGK isoforms underscore their importance in both normal physiology and disease states, highlighting the relevance of DGK-epsilon monoclonal antibody (AA9) in research focused on cellular signaling mechanisms and related disorders.

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DGK-ε Antibody (AA9) References:

1. Mammalian diacylglycerol kinases, a family of lipid kinases with signaling functions.  |  Topham, MK. and Prescott, SM. 1999. J Biol Chem. 274: 11447-50. PMID: 10206945
2. Purification, cDNA-cloning and expression of human diacylglycerol kinase.  |  Schaap, D., et al. 1990. FEBS Lett. 275: 151-8. PMID: 2175712
3. Molecular cloning and expression of a 90-kDa diacylglycerol kinase that predominantly localizes in neurons.  |  Goto, K. and Kondo, H. 1993. Proc Natl Acad Sci U S A. 90: 7598-602. PMID: 7689223
4. Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in human retina with a truncated and inactive enzyme expression in most other human cells.  |  Kai, M., et al. 1994. J Biol Chem. 269: 18492-8. PMID: 8034597
5. Drosophila retinal degeneration A gene encodes an eye-specific diacylglycerol kinase with cysteine-rich zinc-finger motifs and ankyrin repeats.  |  Masai, I., et al. 1993. Proc Natl Acad Sci U S A. 90: 11157-61. PMID: 8248222
6. Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases.  |  Sakane, F., et al. 1996. J Biol Chem. 271: 8394-401. PMID: 8626538
7. Molecular cloning of a novel human diacylglycerol kinase highly selective for arachidonate-containing substrates.  |  Tang, W., et al. 1996. J Biol Chem. 271: 10237-41. PMID: 8626589
8. Cloning and characterization of a glucocorticoid-induced diacylglycerol kinase.  |  Klauck, TM., et al. 1996. J Biol Chem. 271: 19781-8. PMID: 8702685
9. The cloning and characterization of a novel human diacylglycerol kinase, DGKiota.  |  Ding, L., et al. 1998. J Biol Chem. 273: 32746-52. PMID: 9830018

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DGK-ε Antibody (AA9) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-DGK-ε Antibody (AA9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DGK-ε Antibody (AA9) Specifications

Alternate Product Name: DGK-ε

Product Clone Name: AA9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ lambda light chain

Amino Acids: 141-241

Epitope Target: DGK-ε

Epitope Species: human

Product Reactivity/Detection: DGK-ε

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₃ lambda light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for DGK-ε Antibody (AA9): N/A