Dexras1/2 Antibody (C-11): sc-398988
- Dexras1/2 Antibody (C-11) is a mouse monoclonal IgG1 κ Dexras1/2 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 221-249 near the C-terminus of Dexras2 of human origin
- Dexras1/2 Antibody (C-11) is recommended for detection of Dexras1 and Dexras2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Dexras1/2 Antibody (C-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Dexras1/2 Antibody (C-11) for WB applications. These reagents are now offered in bundles with Dexras1/2 Antibody (C-11) (see ordering information below).
Dexras1/2 Antibody (C-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects Dexras1/2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Dexras1/2 (C-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Dexras1, also known as RASD1, is a steroid hormone-dependent, Ras-related GTPase that plays a crucial role in regulating cell morphology, growth, and interactions with the extracellular matrix, making Dexras1 vital for maintaining cellular architecture and function. Dexras1 is involved in modulating receptor-mediated signaling pathways, particularly those associated with Gbeta/gamma (heterotrimeric G protein) signaling, and couples NMDA receptor activity and light input to Gi/o and extracellular signal-regulated kinase (ERK) activation. Dexras2, also referred to as Rhes, is predominantly expressed in the striatal region of the brain and is implicated in mediating signal transduction cascades influenced by dopamine, which may affect dopamine receptor sensitivity. Both Dexras1 and Dexras2 define a unique subfamily within the Ras family, characterized by an extended variable domain in their carboxyl terminal region, highlighting their distinct functional roles in cellular signaling and neurobiology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Dexras1/2 Antibody (C-11) References:
- Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON. | Fang, M., et al. 2000. Neuron. 28: 183-93. PMID: 11086993
- Dexras1/AGS-1 inhibits signal transduction from the Gi-coupled formyl peptide receptor to Erk-1/2 MAP kinases. | Graham, TE., et al. 2002. J Biol Chem. 277: 10876-82. PMID: 11751935
- The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors. | Vargiu, P., et al. 2004. Oncogene. 23: 559-68. PMID: 14724584
- Dexras1 inhibits adenylyl cyclase. | Graham, TE., et al. 2004. Biochem Biophys Res Commun. 316: 307-12. PMID: 15020218
- Rhes is involved in striatal function. | Spano, D., et al. 2004. Mol Cell Biol. 24: 5788-96. PMID: 15199135
- Resetting the clock: Dexras1 defines a path. | Van Gelder, RN. 2004. Neuron. 43: 603-4. PMID: 15339641
- Dexras1 potentiates photic and suppresses nonphotic responses of the circadian clock. | Cheng, HY., et al. 2004. Neuron. 43: 715-28. PMID: 15339652
- Dexras1 blocks receptor-mediated heterologous sensitization of adenylyl cyclase 1. | Nguyen, CH. and Watts, VJ. 2005. Biochem Biophys Res Commun. 332: 913-20. PMID: 15913563
- Monomeric G-protein, Rhes, is not an imidazoline-regulated protein in pancreatic beta-cells. | Sharoyko, VV., et al. 2005. Biochem Biophys Res Commun. 338: 1455-9. PMID: 16277977
- Rhes, the Ras homolog enriched in striatum, is reduced under conditions of dopamine supersensitivity. | Harrison, LM. and LaHoste, GJ. 2006. Neuroscience. 137: 483-92. PMID: 16352400
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dexras1/2 Antibody (C-11) | sc-398988 | 200 µg/ml | $316.00 | |||
Dexras1/2 Antibody (C-11): m-IgG Fc BP-HRP Bundle | sc-527839 | 200 µg Ab; 10 µg BP | $354.00 | |||
Dexras1/2 Antibody (C-11): m-IgG1 BP-HRP Bundle | sc-533212 | 200 µg Ab; 20 µg BP | $354.00 | |||
Dexras1/2 Antibody (C-11) AC | sc-398988 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Dexras1/2 Antibody (C-11) HRP | sc-398988 HRP | 200 µg/ml | $316.00 | |||
Dexras1/2 Antibody (C-11) FITC | sc-398988 FITC | 200 µg/ml | $330.00 | |||
Dexras1/2 Antibody (C-11) PE | sc-398988 PE | 200 µg/ml | $343.00 | |||
Dexras1/2 Antibody (C-11) Alexa Fluor® 488 | sc-398988 AF488 | 200 µg/ml | $357.00 | |||
Dexras1/2 Antibody (C-11) Alexa Fluor® 546 | sc-398988 AF546 | 200 µg/ml | $357.00 | |||
Dexras1/2 Antibody (C-11) Alexa Fluor® 594 | sc-398988 AF594 | 200 µg/ml | $357.00 | |||
Dexras1/2 Antibody (C-11) Alexa Fluor® 647 | sc-398988 AF647 | 200 µg/ml | $357.00 | |||
Dexras1/2 Antibody (C-11) Alexa Fluor® 680 | sc-398988 AF680 | 200 µg/ml | $357.00 | |||
Dexras1/2 Antibody (C-11) Alexa Fluor® 790 | sc-398988 AF790 | 200 µg/ml | $357.00 | |||
Dexras1/2 (C-11) Neutralizing Peptide | sc-398988 P | 100 µg/0.5 ml | $68.00 |