Dermcidin Antibody (G-81): sc-33656

Dermcidin Antibody (G-81) is a mouse monoclonal IgM kappa light chain antibody that detects Dermcidin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Dermcidin antibody (G-81) is available as non-conjugated format. Dermcidin, encoded by the Dermcidin gene, plays a crucial role in innate immune response by producing antimicrobial peptides that help protect against infections. Dermcidin (G-81) antibody recognizes protein constitutively expressed in sweat glands and secreted into sweat, where antimicrobial peptides are transported to the epidermal surface, protecting against various pathogenic microorganisms. This function provides a first line of defense against skin infections. Research has shown Dermcidin overexpression in breast cancer cells promotes cell growth and survival, associated with a focal copy number gain of its locus on human chromosome 12q13.2, highlighting potential roles in cancer biology.

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Dermcidin Antibody (G-81) References:

1. Dermcidin: a novel human antibiotic peptide secreted by sweat glands.  |  Schittek, B., et al. 2001. Nat Immunol. 2: 1133-7. PMID: 11694882
2. Detection of dermcidin-derived peptides in sweat by ProteinChip technology.  |  Flad, T., et al. 2002. J Immunol Methods. 270: 53-62. PMID: 12379338
3. Cathelicidin anti-microbial peptide expression in sweat, an innate defense system for the skin.  |  Murakami, M., et al. 2002. J Invest Dermatol. 119: 1090-5. PMID: 12445197
4. A neural survival factor is a candidate oncogene in breast cancer.  |  Porter, D., et al. 2003. Proc Natl Acad Sci U S A. 100: 10931-6. PMID: 12953101
5. Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense.  |  Murakami, M., et al. 2004. J Immunol. 172: 3070-7. PMID: 14978112
6. Dermcidin is constitutively produced by eccrine sweat glands and is not induced in epidermal cells under inflammatory skin conditions.  |  Rieg, S., et al. 2004. Br J Dermatol. 151: 534-9. PMID: 15377337
7. Deficiency of dermcidin-derived antimicrobial peptides in sweat of patients with atopic dermatitis correlates with an impaired innate defense of human skin in vivo.  |  Rieg, S., et al. 2005. J Immunol. 174: 8003-10. PMID: 15944307
8. The dermcidin gene in cancer: role in cachexia, carcinogenesis and tumour cell survival.  |  Stewart, GD., et al. 2008. Curr Opin Clin Nutr Metab Care. 11: 208-13. PMID: 18403914
9. Variation in dermcidin expression in a range of primary human tumours and in hypoxic/oxidatively stressed human cell lines.  |  Stewart, GD., et al. 2008. Br J Cancer. 99: 126-32. PMID: 18594538
10. A Positive Dermcidin Expression Is an Unfavorable Prognostic Marker for Extramammary Paget's Disease.  |  Ohmori, S., et al. 2021. Diagnostics (Basel). 11: PMID: 34198581
11. The relation of dermcidin with insulin resistance and inflammation in women with polycystic ovary syndrome.  |  Akan, OY. and Bilgir, O. 2022. Rev Assoc Med Bras (1992). 68: 820-826. PMID: 35766698
12. Bone Marrow Mesenchymal Stem Cell-Derived Dermcidin-Containing Migrasomes enhance LC3-Associated Phagocytosis of Pulmonary Macrophages and Protect against Post-Stroke Pneumonia.  |  Li, T., et al. 2023. Adv Sci (Weinh). 10: e2206432. PMID: 37246283

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Dermcidin Antibody (G-81) has 19 citations in a variety of scientific publications.

Primary antibodies like Anti-Dermcidin Antibody (G-81) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Dermcidin Antibody (G-81) Specifications

Alternate Product Name: DCD

Product Clone Name: G-81

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: Dermcidin

Epitope Species: human

Product Reactivity/Detection: Dermcidin precursor and DCD-1 active peptide

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 19 citations in various scientific publications

Available Conjugates/Forms for Dermcidin Antibody (G-81): N/A