DENND2D Antibody (H-6): sc-398374

DENND2D Antibody (H-6) is a mouse monoclonal IgG3 kappa light chain antibody that detects DENND2D protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-DENND2D antibody (H-6) is available as the non-conjugated monoclonal isotype antibody. DENND2D protein consists of 471 amino acids, features a dDENN domain, a DENN domain, and a uDENN domain, and exists in two isoforms due to alternative splicing. DENND2D protein plays a crucial role in targeting actin filaments and regulating Rab9-dependent trafficking of the mannose-6-phosphate receptor to lysosomes, which is essential for proper lysosomal function and cellular waste management. The gene encoding DENND2D is located on human chromosome 1, the largest chromosome in the human genome, which spans approximately 260 million base pairs and constitutes about 8% of the genome. Notably, chromosome 1 also harbors other significant genes, such as LMNA, linked to Hutchinson-Gilford progeria, and the MUTYH gene, associated with familial adenomatous polyposis, highlighting the importance of this chromosomal region in various genetic disorders.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

DENND2D Antibody (H-6) References:

1. Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family.  |  Blackwood, DH., et al. 2001. Am J Hum Genet. 69: 428-33. PMID: 11443544
2. New insights into the evolution of chromosome 1.  |  Weise, A., et al. 2005. Cytogenet Genome Res. 108: 217-22. PMID: 15545733
3. Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody.  |  McClintock, D., et al. 2006. Proc Natl Acad Sci U S A. 103: 2154-9. PMID: 16461887
4. Cell biology: ageing nucleus gets out of shape.  |  Lans, H. and Hoeijmakers, JH. 2006. Nature. 440: 32-4. PMID: 16511477
5. Chromosome 1 abnormalities in multiple myeloma.  |  Marzin, Y., et al. 2006. Anticancer Res. 26: 953-9. PMID: 16619492
6. Genes and schizophrenia: beyond schizophrenia: the role of DISC1 in major mental illness.  |  Hennah, W., et al. 2006. Schizophr Bull. 32: 409-16. PMID: 16699061
7. The DNA sequence and biological annotation of human chromosome 1.  |  Gregory, SG., et al. 2006. Nature. 441: 315-21. PMID: 16710414
8. Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1.  |  Watson, ML., et al. 1990. J Exp Med. 172: 263-72. PMID: 1694218
9. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.  |  Yoshimura, S., et al. 2010. J Cell Biol. 191: 367-81. PMID: 20937701

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DENND2D Antibody (H-6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-DENND2D Antibody (H-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DENND2D Antibody (H-6) Specifications

Alternate Product Name: DENND2D

Product Clone Name: H-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 208-233

Epitope Target: DENND2D

Epitope Species: human

Product Reactivity/Detection: DENND2D

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for DENND2D Antibody (H-6): P: Blocking Peptide